Evan Patel

BS Chemistry, Yale University, 2015

As an undergraduate, I primarily conducted research in organic chemistry with a focus on the synthesis of clinically relevant molecules. While in the lab of Dr. Jonathan Ellman I worked on more efficient synthesis of trisubstituted nitroalkenes using urea organocatalysts. I also spent a summer in the lab of Dr. Stephen Hashmi where I characterized the efficiency and enantioselectivity of gold-catalyzed allene cyclizations. As a medical student at Northwestern University Feinberg School of Medicine, I realized that I want to emphasize laboratory/translational research on biomolecular mechanisms as part of my career in academic medicine. I became an HHMI Medical Fellow in the Littman lab where I hope to further elucidate the effects of gut microbiota on distal tumors and immune checkpoint blockade with the anticipation that a more fundamental knowledge of this process will improve the scope of antitumor immunotherapies.

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Publications:

1. Phelan, J., Patel, E., Ellman, J. Catalytic Enantioselective Addition of Thioacids to Trisubstituted Nitroalkenes. Angew. Chem. Int. Ed. 2014; 53: 11329-11332.