Henry Nguyen, MD
Gastroenterology and Hepatology Fellow
Queens University, 2012
My early academic career started during the completion of my undergraduate studies in cellular and molecular biology. During this time, my translational research work as an undergraduate involved evaluating aberrant immune responses and sickness behavior in the setting of various models of liver disease/injury. In particular, my research focus was on differential processing of TNF-alpha and its effect on liver injury and sickness behavior in the setting of cholestasis. This work was done in the hopes of better elucidating the role of the immune response in driving liver injury and symptoms of fatigue in patients with chronic autoimmune liver disease; an area of unmet need with limited treatment options.
After completion of my undergraduate degree, I went on to obtain an MD at Queen’s University. Subsequently, I was successful in obtaining the Fellow of the Royal College of Physicians of Canada designation (FRCPC) in both Internal Medicine and Adult Gastroenterology. I have since also undergone advanced clinical fellowship training in Hepatology. The duality of my clinical training and concurrent research work throughout my career has underlined the unmet needs in patient care that can be better addressed through basic science research work. The development of precision medicine, where metabolic, immunologic, and microbiome platforms/tools can be used to individualize care, is a current area of need. Our understanding of the interaction between the microbiota and the host immune response in various gut and liver diseases has broadened within the past few years. However, the underlying molecular mechanisms of this process is not yet fully understood.
Undertaking this research fellowship with Dr. Littman will allow me to use the cutting-edge tools developed in his laboratory to better understand the interaction between various immune cells (particularly T-cells) and host microbes in the setting of various gastrointestinal and liver disease states.
1. Shaheen A.A., Nguyen H.H., Congly S.E., Kaplan G.G., Swain M.G. 2019. Nationwide Estimates and Risk Factors of Hospital Readmission in Patients with Cirrhosis in the United States. Liver Int. 2019 Jan 28. doi: 10.1111/liv.14054
2. Nguyen H.H., Shaheen A., Baeza N., Lytvyak E., Urbanski S.J, Mason A.L., Norman G.L., Fritzler M.J, and Swain M.G. 2018. Evaluation of Classical and Novel Autoantibodies for the Diagnosis of Primary Biliary Cholangitis-Autoimmune Hepatitis Overlap Syndrome (PBC-AIH OS). PLOS ONE. 2018 Mar 19;13(3):e0193960.
3. Nguyen H.H., Khathlan A., Swain M.G. 2018. A case series evaluating the impact of Hepatitis C eradication using direct acting antivirals on primary biliary cholangitis-associated autoimmunity. BMC Gastroenterol. 2018 Jun 25;18(1):97
4. Nguyen H.H., Bechara R., Paterson W.G., Hookey L.C. 2018. Two Year Retrospective Analysis of Patients Undergoing Direct to Flexible Sigmoidoscopy Investigation with Rectal Bleeding as a Primary Complaint. Endoscopy International Open Aug 2018; 06: E1059–E1064.
5. Nguyen H.H., Swain M.G., Wong P., Congly S.E. 2018. Driving under the influence of hepatic encephalopathy: A review of Canadian regulations and legal ramifications. CMAJ Open. 2018 Dec 3;6(4):E575-E579
6. Nguyen H.H. and Beck P.L. 2017. Not Your Ordinary Ulcer: A Cautionary Tale of an Uncommon Condition. Gastroenterology. 2017 Dec;153(6):1484-1485
7. Nguyen H.H, Tierney S, Baranchuk A. 2010. Sleep Apnea & Ventricular Arrhythmias: Interaction and Clinical Implications. Revista Iberoamericana de Arritmologia (RIA). Online publication. http://www.ria-online.com/webapp/journal/show/id/RIA10111
8. Nguyen H.H., Wang H., Le T., Ho W., Sharkey K.A., Swain M.G. 2008. Down Regulated hypothalamic 5-HT3 receptor expression and enhanced 5-HT3 receptor antagonistmediated improvement fatigue-like behavior in cholestatic rats. Neurogastroenterol Motil. 20(3): 228-235.
9. Kerfoot S.M., D’Mello C., Nguyen H.H., Ajuebor M.N., Kubes P., Le T., and Swain M.G. 2006. TNF-α Secreting Monocytes Are Recruited Into the Brain of Cholestatic Mice. Hepatology. 43: 154-162.