Lin Wu, PhD

PhD Biochemistry, Hong Kong University of Science and Technology, 2012

My thesis work is about biochemical and structural characterization of Usher Syndrome I protein complexes. Mainly using biochemical and biophysical methods, I identified all interaction sites of five Usher syndrome I proteins, and got the molecular structures of all protein complexes by collaborating with protein structurists. Our research offers a reliable interaction network of Usher I proteins, which was debatable by then. And combined with published in vivo data, our biochemical characterization provides explanation about how the tip link is organized and why such a fragile machinery can sustain strong sound wave impacts.

Currently in the Littman Lab, I'm interested in studying key molecules that dictate Th17 cell development and its pathogenicity in autoimmune diseases. 

 
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Publications:

1. Wu Lin, Pan Lifeng, Wei Zhiyi, and Zhang Mingjie. (2011). Structure of MyTH4-FERM Domains in Myosin VIIa Tail Bound to Cargo" Science 331(6018):757-60

2. Wu Lin, Pan Lifeng, Zhang Chuchu, and Zhang Mingjie. (2012). Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia” J Biol Chem. 28;287(40):33460-71

3. Pan Lifeng, Yan Jing, Wu Lin and Zhang Mingjie. (2009). Assembling Stable Hair-Cell Tip Link Complex via Multi-dentate Interactions between Harmonin and Cadherin23" PNAS. 106 5575-5580

4. Yan Jing, Pan Lifeng, Chen Xiuye, Wu Lin, Zhang Mingjie. (2010). The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins. PNAS. 107 4040-5