Lina Kroehling

MS Biochemistry, Clark University 2015

My Masters work focused on the biophysics of protein misfolding and self-assembly that is associated with disease, in particular that of islet amyloid polypeptide (IAPP) in type 2 diabetes. Following my masters I transitioned from the wet lab to the dry lab, and worked as a bioinformatician analyzing primarily sequencing data such as RNA-seq, ChIP-seq, ATAC-seq, and Ribosome Profiling. In the Littman lab, I provide sequencing analyses and visualization support. 



1. Ruaidhrí Jackson, Lina Kroehling, Alexandra Khitun, Will Bailis, Abby Jarret, Autumn York, Omair Khan, J. Richard Brewer, Mathias H. Skadow, Coco Duizer, Christian C.D. Harman, Lelina Chang, Piotr Bielecki, Angel Solis, Holly R. Steach, Sarah Slavoff and Richard A. Flavell. The Translation of Non-Canonical Open Reading Frames Controls Mucosal Immunity. Nature. Accepted. 2018.

2. Li, H. B., Tong, J., Zhu, S., Batista, P. J., Duffy, E. E., Zhao, J., Bailis, W., Cao, G., Kroehling, L., Chen, Y., Wang, G., Broughton, J. P., Chen, Y. G., Kluger, Y., Simon, M. D., Chang, H. Y., Yin, Z., … Flavell, R. A. (2017). m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Nature548(7667), 338-342.

3. Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA. KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity. 2018 Apr;48(4) 716-729.e8. doi:10.1016/j.immuni.2018.03.015. PMID: 29625895.