Our Favorite papers

Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR. (2015) An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell. 2015 Oct 8;163(2):381-93 [Pubmed]

Yang Y, Torchinsky MB, Gobert M, Xiong H, Xu M, Linehan JL, Alonzo F, Ng C, Chen A, Lin X, Sczesnak A, Liao JJ, Torres VJ, Jenkins MK, Lafaille JJ, Littman DR. (2014) Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature. 510(7503):152-6. 

Ivanov, I.I., Atarashi, K., Manel, N., Brodie, E.L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K.C., Santee, C.A., Lynch, S.V., Tanoue, T., Imaoka, A., Itoh, K., Takeda, K., Umesaki, Y., Honda, K., & Littman, D.R.  (2009) Induction of intestinal Th17 cells by Segmented Filamentous Bacteria.  Cell 139(3), 485-98. Epub 2009 Oct 15.  PMC2796826.


Full Publication List

Link to list of Littman publications: Click Here



Ng, C., Aichinger, M., Nguyen, T.*, Au, C.*, Najar, T., Wu,L., Mesa, K.R., Liao, W., Quivy, J.P., Hubert, B., Almouzni, G., Zuber, J., Littman, D.R. (2019). The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells. Genes & Dev. 2019 Apr 11. doi: 10.1101/gad.322024.118. PMID: 30975723



Issuree, P.D., Day, K., Au, C., Raviram, R., Zappile, P., Skok, J.A., Xue, H.-H., Myers, R.M., and Littman, D.R. (2018). Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development. Nature Communications 9, 3594. Open access: https://rdcu.be/5Q18


Xu, M.*, Pokrovskii, M.*, Ding, Y., Yi, R., Au, C., Harrison, O.J., Galan, C., Belkaid, Y., Bonneau, R., Littman, D.R. (2018) c-Maf-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature. 2018 Feb 15;554(7692):373-377. [PubMed]




Littman, D.R. (2017) Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens? If So, Is There Potential for Efficacious Microbiota-Based Vaccines? Cold Spring Harb. Perspect. Biol. pii: a029355. doi: 10.1101/cshperspect.a029355. [Epub ahead of print] PubMed PMID: 28432131.


Issuree, P.D., Ng, C.P., Littman, D.R. (2017) Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice. Front. Immunol. 8:291. PMCID: PMC5360760.


Cheung, K.L., Zhang, F., Jaganathan, A., Sharma, R., Zhang, Q., Konuma, T., Shen, T., Lee, J.Y., Ren, C., Chen, C.H., Lu, G., Olson, M.R., Zhang, W., Kaplan, M.H., Littman, D.R., Walsh, M.J., Xiong, H., Zeng, L., Zhou, M.M. (2017) Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation. Mol. Cell. 65(6):1068-1080.e5. PMCID: PMC5357147.


Urlep, Ž., Lorbek, G., Perše, M., Jeruc, J., Juvan, P., Matz-Soja, M., Gebhardt, R., Björkhem, I., Hall, J.A., Bonneau, R., Littman, D.R., Rozman, D. (2017) Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling. Sci. Rep. 7:40775. PMCID: PMC5241696.


Isaac, S., Scher, J.U., Djukovic, A., Jiménez, N., Littman, D.R., Abramson, S.B., Pamer, E.G., Ubeda, C. (2017) Short- and long-term effects of oral vancomycin on the human intestinal microbiota. J. Antimicrob. Chemother. 72(1):128-136. PMCID: PMC5161046.




Ménager, M.M., Littman, D.R. (2016) Quantitative Measurements of HIV-1 and Dextran Capture by Human Monocyte-derived Dendritic Cells (MDDCs). Bio Protoc. 6(22). pii: e2004. doi: 10.21769/BioProtoc.2004. PMC5432018.


Coffre, M., Benhamou, D., Rieß, D., Blumenberg, L., Snetkova, V., Hines, M.J., Chakraborty, T., Bajwa, S., Jensen, K., Chong, M.M., Getu, L., Silverman, G.J., Blelloch, R., Littman, D.R., Calado, D., Melamed, D., Skok, J.A., Rajewsky, K., Koralov, S.B. (2016) miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation. Cell Rep. 17(9):2271-2285


Honda, K & Littman, D. R. (2016).  The microbiota in adaptive immune homeostasis and disease.  Nature. 535, 75-84. PMID: 27383982


Ng, C.P. &Littman, D.R. (2016) Tcf1 and Lef1 pack their own HDAC.  Nat Immunol. 17, 615-6. PMID: 27196513


Littman, D.R. (2016) How thymocytes achieve their fate.  J. Immunol. 196, 1983-4.  PMID:  26896481


Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA, Littman DR, Huh JR. (2016) The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science. 2016 Feb 26;351(6276):933-9 [Pubmed]


Ménager MM, Littman DR. (2016) Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells. Cell. 2016 Feb 11;164(4):695-709 [Pubmed]




Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR. (2015) An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell. 2015 Oct 8;163(2):381-93 [Pubmed]


Sellars M, Huh JR, Day K, Issuree PD, Galan C, Gobeil S, Absher D, Green MR, Littman DR. (2015) Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages. Nat Immunol. 16(7):746-54. [Pubmed]


Santori FR, Huang P, van de Pavert SA, Douglass EF Jr, Leaver DJ, Haubrich BA, Keber R, Lorbek G, Konijn T, Rosales BN, Rozman D, Horvat S, Rahier A, Mebius RE, Rastinejad F, Nes WD, Littman DR. (2015) Identification of natural RORγ ligands that regulate the development of lymphoid cells. Cell Metab. 21(2):286-97. [Pubmed]




Longman RS, Diehl GE, Victorio DA, Huh JR, Galan C, Miraldi ER, Swaminath A, Bonneau R, Scherl EJ, Littman DR. (2014) CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Ex Med. 211(8):1571-83. [Pubmed]


Yang Y, Torchinsky MB, Gobert M, Xiong H, Xu M, Linehan JL, Alonzo F, Ng C, Chen A, Lin X, Sczesnak A, Liao JJ, Torres VJ, Jenkins MK, Lafaille JJ, Littman DR. (2014) Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature. 510(7503):152-6. [Pubmed]


van de Pavert SA, Ferreira M, Domingues RG, Ribeiro H, Molenaar R, Moreira-Santos L, Almeida FF, Ibiza S, Barbosa I, Goverse G, Labão-Almeida C, Godinho-Silva C, Konijn T, Schooneman D, O'Toole T, Mizee MR, Habani Y, Haak E, Santori FR, Littman DR, Schulte-Merker S, Dzierzak E, Simas JP, Mebius RE, Veiga-Fernandes H. (2014) Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature. 508(7494):123-7. [Pubmed]




Kruglov, A.A., Grivennikov, S.I., Kuprash, D.V., Winsauer, C., Prepens, S., Seleznik, G.M., Eberl, G., Littman, D.R., Heikenwalder, M., Tumanov, A.V., Nedospasov, S.A. (2013) Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science. 342(6163):1243-6. [Pubmed]


Parkhurst, C.N., Yang, G., Ninan, I., Savas, J.N., Yates, J.R. 3rd, Lafaille, J.J., Hempstead, B.L., Littman, D.R., Gan, W.B. (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 155(7):1596-609. [Pubmed]


Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, Bielski C, Rostron T, Cerundolo V, Pamer EG, Abramson SB, Huttenhower C, Littman DR. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife 2013. [Pubmed]


Seay, K., Qi, X., Zheng, J.H., Zhang, C., Chen, K., Dutta, M., Deneroff, K., Ochsenbauer, C., Kappes, J.C., Littman, D.R., & Goldstein, H. (2013) Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy. PLoS One. 8(5):e63537. [Pubmed]


Kim SV, Xiang WV, Kwak C, Yang Y, Lin XW, Ota M, Sarpel U, Rifkin DB, Xu R, Littman DR. GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science 2013. [Pubmed]


Streeck, H., D’Souza, M.P., Littman, D.R., & Crotty, S. (2013) Harnessing CD4+ T cell responses in HIV vaccine development. Nature Medicine 19:143-9. PMC3626561.


Diehl GE, Longman RS, Zhang JX, Breart B, Galan C, Cuesta A, Schwab SR, Littman DR. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature 2013. [Pubmed]


Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP, Johnson RL, Huang W, Littman DR. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. ACS Med Chem Lett 2013. [Pubmed]




Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, Kirigin FK, Birchmeier C, Wagner EF, Murphy KM, Myers RM, Bonneau R, Littman DR. A validated regulatory network for Th17 cell specification. Cell. 2012. [Pubmed]


Weiss, J.M., Bilate, A.M., Gobert, M., Ding, Y., Curotto de Lafaille, M.A., Parkhurst, C.N., Xiong, H., Dolpady, J., Frey, A.B., Ruocco, M.G., Yang, Y., Floess, S., Huehn, J., Oh, S., Li, M.O., Niec, R.E., Rudensky, A.Y., Dustin, M.L., Littman, D.R., Lafaille, J.J. (2012) Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J. Exp. Med. 209:1723-42. PMC3457733.


Glasmacher, E., Agrawal, S., Chang, A.B., Murphy, T.L., Zeng, W., Vander Lugt, B., Khan, A.A., Ciofani, M., Spooner, C.J., Rutz, S., Hackney, J., Nurieva, R., Escalante, C.R., Ouyang, W., Littman, D.R., Murphy, K.M., Singh, H. (2012) A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science. 338:975-80.


Fulton, L.M., Carlson, M.J., Coghill, J.M., Ott, L.E., West, M.L., Panoskaltsis-Mortari, A., Littman, D.R., Blazar, B.R. & Serody, J.S. (2012) Attenuation of Acute Graft-versus-Host Disease in the Absence of the Transcription Factor RORγt. J. Immunol. 189(4):1765-72. PMC3411855.


Knuckles, P., Vogt, M.A., Lugert, S., Milo, M., Chong, M.M., Hautbergue, G.M., Wilson, S.A., Littman, D.R. & Taylor, V. (2012) Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs.  Nat. Neurosci. 15(7): 962-9.


Hooper, L.V., Littman, D.R. & Macpherson, A.J. (2012) Interactions between the microbiota and the immune system.  Science 336(6086), 1268-73.


Scher JU, Ubeda C, Equinda M, Khanin R, Buischi Y, Viale A, Lipuma L, Attur M, Pillinger MH, Weissmann G, Littman DR, Pamer EG, Bretz WA, Abramson SB. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum 2012. [Pubmed]


Huh JR, Littman DR. Small molecule inhibitors of RORγt: targeting Th17 cells and other applications. Eur J Immunol. 2012. [Pubmed]

Xu, C., Shen, Y., Littman, D.R., Dustin, M.L. & Velasquez, P. (2012) Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy.  J. Leukoc. Biol. 92(3):413-9. PMC3427606.


Teta, M., Choi, Y.S., Okegbe, T., Wong, G., Tam, O.H., Chong, M.M., Seykora, J.T., Nagy, A., Littman, D.R., Andl, T. & Millar, S.E. (2012)  Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin.  Development 139(8), 1405-16.  PMC3308177.


Longman, R.S., Moreira, R.K., Littman, D.R., Green, P.H. & Sethi, A. (2012) A rare intestinal infection with systemic effects.  Gastroenterol. Hepatol. (N.Y.) 8(1), 60-3.  PMC3277202.


Kinnebrew, M.A., Buffie, C.G., Diehl, G.E., Zenewicz, L.A., Leiner, I., Hohl, T.M., Flavell, R.A., Littman, D.R. & Pamer, E.G. (2012) Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.  Immunity 36(2), 276-87.  PMC3288454.


Kirigin FF, Lindstedt K, Sellars M, Ciofani M, Low SL, Jones L, Bell F, Pauli F, Bonneau R, Myers RM, Littman DR, Chong MM. Dynamic microRNA gene transcription and processing during T cell development. J Immunol. 2012. [Pubmed]

Honda, K. & Littman, D.R. (2012) The microbiome in infectious disease and inflammation.  Ann. Rev. Immunol. 30, 759-95.




Littman DR, Pamer EG. Role of the commensal microbiota in normal and pathogenic host immune responses. Cell Host Microbe. 2011. [Pubmed] 

Manel, N. and Littman, D.R. (2011) Hiding in plain sight: how HIV evades innate immune responses. Cell 147(2), 271-4.


Egawa, T. and Littman, D.R. (2011) Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene. Proc. Natl. Acad. Sci. U.S.A. 108(36), 14873-8. PMC3169121.


Gialitakis, M., Sellars, M. and Littman, D.R. (2011) The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression. Curr. Top. Microbiol. Immunol.  356, 165-88.


Sczesnak A, Segata N, Qin X, Gevers D, Petrosino JF, Huttenhower C, Littman DR, Ivanov II. The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe. 2011. [Pubmed]

Zhdanova, O., Srivastava, S., Di, L., Li, Z., Tchelebi, L., Dworkin, S., Johnstone, D.B., Zavadil, J., Chong, M.M., Littman, D.R., Holzman, L.B., Barisoni, L. & Skolnik, E.Y. (2011) The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy.  Kidney Int.  80(7), 719-30. PMC3246347.


Sujino, T., Kanai, T., Ono, Y., Mikami, Y., Hayashi, A., Doi, T., Matsuoka, K., Hisamatsu, T., Takaishi, H., Ogata, H., Yoshimura, A., Littman, D.R. & Hibi, T. (2011) Regulatory T Cells Suppress the Development of Colitis, Blocking Differentiation of T-helper 17 Into Alternative T-Helper 1 Cells. Gastroenterology 141(3), 1014-23.


Egawa T, Littman DR. Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene. Proc Natl Acad Sci USA. 2011. [Pubmed]

Sujino, T., Kanai, T., Ono, Y., Mikami, Y., Hayashi, A., Doi, T., Matsuoka, K., Hisamatsu, T., Takaishi, H., Ogata, H., Yoshimura, A., Littman, D.R. & Hibi, T. (2011) Regulatory T Cells Suppress the Development of Colitis, Blocking Differentiation of T-helper 17 Into Alternative T-Helper 1 Cells. Gastroenterology 141(3), 1014-23.


Collins, A., Hewitt, S.L., Chaumeil, J., Sellars, M., Micsinai, M., Allinne, J., Parisi, F., Nora, E.P., Bolland, D.J., Corcoran, A.E., Kluger, Y., Bosselut, R., Ellmeier, W., Chong, M.M., Littman, D.R., & Skok, J.A. (2011) RUNX Transcription Factor-Mediated Association of Cd4 and Cd8 Enables Coordinate Gene Regulation. Immunity 34(3), 303-14.  PMC3101577.


Hovhannisyan, Z., Treatman, J., Littman, D.R. & Mayer, L. (2011) Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases.  Gastroenterology. 140(3), 957-65.  PMC3049831.


Ivanov, I.I. & Littman, D.R. (2011) Modulation of immune homeostasis by commensal bacteria. Curr. Opin. Microbiol. 14(1):106-14.  PMC3123735.


Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B.D., Fowler, B.J., Cho, W.G., Kleinman, M.E., Ponicsan, S.L., Hauswirth, W.W., Chiodo, V.A., Karikó, K., Yoo, J.W., Lee, D.K., Hadziahmetovic, M., Song, Y., Misra, S., Chaudhuri, G., Buaas, F.W., Braun, R.E., Hinton, D.R., Zhang, Q., Grossniklaus, H.E., Provis, J.M., Madigan, M.C., Milam, A.H., Justice, N.L., Albuquerque, R.J., Blandford, A.D., Bogdanovich, S., Hirano, Y., Witta, J., Fuchs, E., Littman, D.R., Ambati, B.K., Rudin, C.M., Chong, M.M., Provost, P., Kugel, J.F., Goodrich, J.A., Dunaief, J.L., Baffi, J.Z., & Ambati, J. (2011) DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature.  471(7338), 325-30. PMC3077055.


Cruz-Orengo, L., Holman, D.W., Dorsey, D., Zhou, L., Zhang, P., Wright, M., McCandless, E.E., Patel, J.R., Luker, G.D., Littman, D.R., Russell, J.H. & Klein, R.S.  (2011) CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity.  J. Exp. Med. 208(2), 327-39. PMC3039853.


Huh, J.R., Leung, M.W.L., Huang, P., Ryan, D.A., Krout, M.R., Malapaka, R.R., Chow, J., Manel, N., Ciofani, M., Kim, S.V., Cuesta, A., Santori, F.R., Lafaille, J.J., Gin, D.Y., Rastinejad, F., & Littman, D.R. (2011)  Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity.  Nature 472(7344), 486-90. PMC3172133.




Chong, M.M.W., Zhang, G., Cheloufi, S., Neubert, T., Hannon, G.J., & Littman, D.R. (2010) Canonical and alternate functions of the microRNA biogenesis machinery.  Genes & Dev. 24(17), 1951-60.  PMC2932976.


Manel, N., Hogstad, B., Wang, Y., Levy, D.E., Unutmaz, D. & Littman, D.R. (2010)  A cryptic sensor for HIV-1 activates innate immunity in dendritic cells.  Nature, 467(7312), 214-7.  PMC3051279.


Buonocore, S., Ahern, P.P., Uhlig, H.H., Ivanov, I.I., Littman, D.R., Maloy, K.J., & Powrie, F. (2010) Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464(7293), 1371-5.


Lee, K., Ambrose, Z., Martin, T.D., Oztop, I., Mulky, A., Julias, J.G., Vandengraaff, N., Baumann, J.G., Wang, R., Yuen, W., Takemura, T., Shelton, K., Taniuchi, I., Li, Y., Sodroski, J., Littman, D.R., Coffin, J.M., Hughes, S.H., Unutmaz, D., Engelman, A., KewalRamani, V.N. (2010) Flexible use of nuclear import pathways by HIV-1.  Cell Host Microbe 7(3), 221-33.  PMC2841689.


Littman, D.R. & Rudensky, A.Y. (2010) Th17 and regulatory T cells in mediating and restraining inflammation.  Cell 140(6), 845-58.


Chong, M.M.W., Simpson, N., Ciofani, M., Chen, G., Collins, A. & Littman, D.R. (2010) Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells.  Genes & Dev. 24(7), 659-69.  PMC2849123.


El Hed, A., Khaitan, A., Kozhaya, L., Manel, N., Daskalakis, D., Borkowsky, W., Valentine, F., Littman, D.R. & Unutmaz, D. (2010) Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection.  J. Infect. Dis. 201(6), 843-54.  PMC2849315.


Ivanov, I.I. & Littman, D.R. (2010) Segmented filamentous bacteria take the stage.  Mucosal Immunol. 3(3), 209-12.  PMC3010405.


Jacob, B., Osato, M., Yamashita, N., Wang, C.Q., Taniuchi, I., Littman, D.R., Asou, N. & Ito, Y. (2010) Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Blood Epub 2009 Dec 14.  PMC2830765.


Wu, H.-J., Ivanov, I.I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D.R., Benoist, C. & Mathis, D. (2010) Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells.  Immunity 32(6), 815-827.  PMC2904693.


Trampont, P.C., Tosello-Trampont, A.-C., Shen, Y., Duley, A.K., Sutherland, A.E., Bender, T.P.,  Littman, D.R. & Ravichandran K.S. (2010) CXCR4 acts as a costimulator during thymic β-selection. Nat. Immunol. 11(2), 162-70. Epub 2009 Dec 13.  PMC2808461.




Klunker, S., Chong, M.M.W., Mantel, P., Palomares, O., Bassin, C., Ziegler, M., Ruckert, B., Meiler, F., Akdis, M., Littman, D.R., & Akdis, C.A. (2009) Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells.  J. Exp. Med. 206(12), 2701-15. Epub 2009 Nov 16.  PMC2806624.


Kim, J.K., Klinger, M., Benjamin, J., Xiao, Y., Erle, D.J., Littman, D.R., & Killeen, N. (2009) Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking.  PLoS One 4(8):e6580.  Epub 2009 Aug 11.  PMC2719063.


Rudra, D., Egawa, T., Chong, M.M., Treuting, P., Littman, D.R., & Rudensky, A.Y. (2009) Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells.  Nat. Immunol. 10(11), 1170-7. Epub 2009 Sep 20.  PMC2764816.


Feuerer, M., Shen, Y., Littman, D.R., Benoist, C., & Mathis, D. (2009) How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets.  Immunity 31(4), 654-64. Epub 2009 Oct 8.  PMC2998796.


Ivanov, I.I., Atarashi, K., Manel, N., Brodie, E.L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K.C., Santee, C.A., Lynch, S.V., Tanoue, T., Imaoka, A., Itoh, K., Takeda, K., Umesaki, Y., Honda, K., & Littman, D.R.  (2009) Induction of intestinal Th17 cells by Segmented Filamentous Bacteria.  Cell 139(3), 485-98. Epub 2009 Oct 15.  PMC2796826.


Zhou, L., Chong, M.M.W. & Littman, D.R. (2009) Plasticity of CD4+ T cell lineage differentiation.  Immunity 30(5), 646-55.

Zhou, L. & Littman, D.R. (2009) Transcriptional regulatory networks in Th17 cell differentiation.  Curr. Opin. Immunol. 21(2), 146-52.  Epub 2009 Mar 26.  PMC2701391.


Voo, K.S., Wang, Y.H., Santori, F.R., Boggiano, C., Wang, Y.H., Arima, K., Bover, L., Hanabuchi, S., Khalili, J., Marinova, E., Zheng, B., Littman, D.R. & Liu, Y.J. (2009) Identification of IL-17-producing FOXP3+ regulatory T cells in humans.  Proc. Natl. Acad. Sci. U.S.A.  106(12), 4793-8.  Epub 2009 Mar 9.  PMC2653560.


Collins, A., Littman, D.R., & Taniuchi, I. (2009) Runx proteins in transcription factor networks that regulate T-cell lineage choice.  Nat. Rev. Immunol. 9(2), 106-115.


Michel, N., Goffinet, C., Ganter, K., Allespach, I., KewalRamani, V.N., Saifuddin, M., Littman, D.R., Greene, W.C. & Keppler, O.T. (2009) Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo.  Retrovirology Epub 2009 Jan 13. 6:2.  PMC2631513.


Browne, E.P. & Littman, D.R. (2009) Myd88 is required for an antibody response to retroviral infection.  PLoS Pathogens, 5(2):e1000298.  Epub 2009 Feb 13.  PMC2633609.




Kao, H., Lin, J., Littman, D.R., Shaw, A.S., & Allen, P.M. (2008) Regulated movement of CD4 in and out of the immunological synapse.  J. Immunol. 181(12), 8248-57.  PMC2857686.


Takatori, H., Kanno, Y., Watford, W.T., Tato, C.M., Weiss, G., Ivanov, I.I., Littman, D.R. & O’Shea, J.J. (2009) Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22.  J. Exp. Med. Epub 2008 Dec. 29.  206(1), 35-41.  PMC2626689.


Leppkes, M., Becker, C., Ivanov, I.I., Hirth, S., Wirtz, S., Neufert, C., Pouly, S., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Becher, B., Littman, D.R. & Neurath, M.F. (2009) RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.  Gastroenterology 136(1), 257-67. Epub 2008 Oct 9.


Tassi, I., Cella, M., Presti, R., Colucci, A., Gilfillan, S., Littman, D.R., & Colonna, M. (2008) NK cell-activating receptors require PKC-θ for sustained signaling, transcriptional activation, and IFN-γ secretion.  Blood 112(10), 4109-16.  Epub 2008 Sept 10. PMC2581989.


Luci, C., Reynders, A., Ivanov, I.I., Cognet, C., Chiche, L., Chasson, L., Hardwigsen, J., Anguiano, E., Banchereau, J., Chaussabel, D., Dalod, M., Littman, D.R., Vivier, E., & Tomasello, E. (2009) Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin.  Nat. Immunol. 10(1), 75-82. Epub 2008 Nov 23.


Ivanov, I.I., de Llanos Frutos, R., Manel, N., Yoshinaga, K., Rifkin, D.B., Sartor, R.B., Finlay, B.B. & Littman, D.R. (2008) Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.  Cell Host Microbe 4(4), 337-49.  PMC2597589.


Egawa, T. & Littman, D.R. (2008) ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage.  Nat. Immunol.  9(10), 1131-9.  Epub 2008 Sept 7. PMC2666788.


Quezada, S.A., Peggs, K.S., Simpson, T.R., Shen, Y., Littman, D.R. & Allison, J.P. (2008) Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma.  J. Exp. Med. 205(9), 2125-38. Epub 2008 Aug 25. PMC2526206.


Chong, M.M.W., Rasmussen, J.P., Rudensky, A.Y. & Littman, D.R. (2008) The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J. Exp. Med. 205(9), 2005-17.  Epub 2008 Aug 25.  PMC2526196.


Valdez, Y., Diehl, G.E., Vallance, B.A., Grassl, G.A., Guttman, J.A., Brown, N.F., Rosenberger, C.M., Littman, D.R., Gros, P.,  & Finlay, B.B. (2008) Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection.  Cell Microbiol. 10(8), 1646-61. Epub 2008 Apr 23. PMC3051341.


Manel, N., Unutmaz, D., & Littman, D.R.  (2008) The differentiation of human Th17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγT. Nat. Immunol. 9(6), 641-9.  Epub 2008 May 4. PMC2597394.


Tsuji, M., Suzuki, K., Kitamura, H., Maruya, M., Kinoshita, K., Ivanov, I.I., Itoh, K., Littman, D.R. & Fagarasan, S. (2008) Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut.  Immunity 29(2), 261-271. Epub 2008 Jul 24.


Scandella, E., Bolinger, B., Lattmann, E., Miller, S., Favre, S., Littman, D.R., Finke, D, Luther, S.A., Junt, T. & Sudewig, B. (2008) Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nat. Immunol. 9(6), 667-75.  Epub 2008 Apr 20.


Gross, O., Grupp, C., Steinberg, C., Zimmermann, S.,  StrasserD., Hannesschläger, N.,  Reindl, W.,  Jonsson, H.,  Huo, H.,  Littman, D.R.,  Peschel, C.,  Yokoyama, W.M., Krug, A. & Ruland, J. (2008) Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kB and MAPK activation to selectively control cytokine production. Blood 112(6), 2421-8.  Epub 2008 Jan 11. PMC2532811.


Browne, E.P. & Littman, D.R. (2008) Species-specific restriction of apobec3-mediated hypermutation. J. Virol. 82(3), 1305-13.  Epub 2007 Nov 21. PMC2224457.


Egawa, T., Kreslavsky, T., Littman, D.R., & von Boehmer, H. (2008) Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping. PLoS One 3(1):e1512. Epub 2008 Jan 30. PMC2211402.


Zhang, J.X., Diehl, G.E., & Littman, D.R. (2008) Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.  PLoS One 3(4):e2035. Epub 2008 Apr 30. PMC2323578.


Zhou, L., Lopes, J., Chong, M.M.W., Ivanov, I.I., Min, R., Victora, G.D., Shen, Y.,  Du, J., Rubtsov, Y.P., Rudensky, A.Y., Ziegler, S.F. & Littman, D.R. (2008) TGF-β-induced Foxp3 inhibits Th17 cell differentiation by antagonizing RORγt function. Nature 453(7192), 236-40.  Epub 2008 Mar26. PMC2597437.




Ivanov, I.I., Zhou, L., & Littman, D.R. (2007) Transcriptional regulation of Th17 cell differentiation.  Semin. Immunol. 19(6), 409-17. PMC2696342.


Zhou, L., Ivanov, I.I., Spolski, R., Min, R., Shenderov, K., Egawa, T., Levy, D.E., Leonard, W.J. & Littman, D.R. (2007) IL-6 programs Th17 cell differentiation by promoting the sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8(9), 967-74.


Sims, T.N., Soos, T.J., Xenias, H.S., Dubin-Thaler, B.D., Hofman, J.M., Waite, J., Cameron, T.O., Thomas, V.K., Varma, R., Wiggins, C.H., Sheetz, M.P., Littman, D.R., & Dustin, M.L. (2007)  Opposing effects of PKCθ and WASp on the symmetry breaking and relocation of the immunological synapse.  Cell 129(4):773-785.


Egawa, T., Tillman, R.E., Naoe, Y., Taniuchi, I. & Littman, D.R. (2007) The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naïve T cells.  J. Exp. Med. 204(8), 1945-57.  PMC2118679.


Naoe, Y., Setoguchi, R., Akiyama, K., Muroi, S., Kuroda, M., Hatam. F., Littman, D.R. & Taniuchi, I. (2007) Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer. J. Exp. Med. 204(8), 1749-55.  PMC2118685.


Misra, R.S., Russell, J.Q., Koenig, A., Hinshaw-Makepeace, J.A., Wen, R., Wang, D., Huo, H., Littman, D.R., Ferch, U., Ruland, J., Thome, M., Budd, R.C. (2007) Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappa B adaptors during T cell activation. J. Biol. Chem. 282(27), 19365-74.


Boggiano, C. & Littman, D.R. (2007) HIV’s vagina travelogue.  Immunity 26, 145-7.


Littman, D.R. & Singh, H. (2007) Asymmetry and immune memory.  Science 315, 1673-4.


Boggiano, C., Manel, N., & Littman, D.R. (2007) Dendritic cell-mediated trans-enhancement of HIV-1 infectivity is independent of DC-SIGN. J. Virol. 81(5), 2519-23.  PMC1865951.




Ivanov, I.I., Diehl, G.E., & Littman, D.R. (2006) Lymphoid tissue inducer cells in intestinal immunity. In “Gut-associated lymphoid tissues”, Curr. Top. Micro. Immunol. 308, 59-82.


Ivanov, I.I., McKenzie, B.S., Zhou, L., Tadokoro, C.E., Lepelley, A., Lafaille, J.J., Cua, D.J. & Littman, D.R. (2006) The orphan nuclear receptor RORγt directs the differentiation program of pro-inflammatory IL-17+ T helper cells.  Cell 126, 1121-33.


Burns, J.M., Summers, B., Wang, Y., Melikian, A., Berahovich, R., Miao, Z., Penfold, M.E.,  Sunshine, M.J., Littman, D.R., Kuo, C.J., Wei, K., McMaster, B., Wright, K., Howard, M., & Schall, T.J.  (2006)  A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.  J. Exp. Med. 203, 2201-13.


Huang, D., Shi, F.D., Jung, S., Pien, G.C., Wang, J., Salazar-Mather, T.P., He, T.T., Weaver, J.T., Ljunggren, H.G., Biron, C.A., Littman, D.R. & Ransohoff, R.M.  (2006) The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system.  FASEB J. 20, 896-905.


Cardona, A.E., Pioro, E.P., Sasse, M.E., Kostenko, V., Cardona, S.M., Dijkstra, I.M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., Lee, J.C., Cook, D.N., Jung, S., Lira, S.A., Littman, D.R. & Ransohoff, R.M. (2006)  Control of microglial neurotoxicity by the fractalkine receptor.  (2006) Nat Neurosci. 9, 917-24.


Soos, T.J., Sims, T.N., Barisoni, L., Lin, K., Littman, D.R., Dustin, M.L. & Nelson, P.J. (2006)  CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney.  Kidney Int. 70, 591-6.


Fogg, D.K., Sibon, C., Miled, C., Jung, S., Aucouturier, P., Littman, D.R., Cumano, A., & Geissmann, F. (2006) A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311, 83-7.


Sun, J., Soos, T., KewalRamani, V.N., Osiecki, K., Zheng, J.H., Falkin, L., Santambrogio, L., Littman, D.R. & Goldstein, H. (2006) CD4-specific transgenic expression of human cyclin T1 markedly increases HIV-1 production by CD4+ T lymphocytes and myeloid committed cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate.  J. Virol. 80, 1850-62.




Zaft, T., Sapoznikov, A., Krauthgarner, R., Littman, D.R., & Jung, S. (2005) CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naïve and memory CD8+ T cells.  J. Immunol. 175, 6428-35.


Collins, A. & Littman, D.R. (2005) Selection and lineage specification in the thymus: commitment 4-stalled. Immunity 23, 4-5.


Browne, E.P., Li, J., Chong, M., & Littman, D.R. (2005) Virus-host interactions:  new insights from the small RNA world.  Genome Biol. 6, 238.


Vilz, T.O., Moepps, B., Engele, J., Molly, S., Littman, D.R., & Schilling, K. (2005) The SDF- 1/CXCR4 pathway and the development of the cerebellar system. Eur. J. Neurosci., 22, 1831-9.


Ödemis, V., Lamp, E., Pezeshki, G., Moepps, M., Schilling, K, Gierschik, P., Littman, D.R. & Engele J. (2005) Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis.  Mol. Cell. Neurosci., 30, 494-505.


Davalos, D., Grutzendler, J., Yang, G., Kim, J.V., Zuo, Y., Jung, S., Littman, D.R., Dustin, M.L., & Gan, W.B. (2005)  ATP mediates rapid microglial response to local brain injury in vivo.  Nat. Neurosci. 8, 752-8.


Egawa, T., Eberl, G., Taniuchi, I., Benlagha, K., Geissmann, F., Hennighausen, L., Bendelac, A.,  & Littman, D.R. (2005) Genetic evidence supporting selection of the Vα14i NKT cell lineage from double positive thymocyte precursors.  Immunity 22, 705-716.


Wang, X., Blagden, C., Fan, J., Nowak, S., Taniuchi, I., Littman, D.R. & Burden, S.J. (2005) Runx1 prevents wasting, myofibrillar disorganization and autophagy of skeletal muscle.  Genes & Dev., 19, 1715-22.


Niess, J.H., Brand, S., Gu, X., Landsman, L., Jung, J., McCormick, B., Vyas, J.M., Boes, M., Ploegh, H.L., Fox, J.G., Littman, D.R. & Reinecker, H.-C. (2005) CX3CR1 controls access of specialized dendritic cells to the intestinal lumen and clearance of bacteria.  Science 307, 254-258.


Sato, T., Thorlacius, H., Johnston, B., Staton, T.L., Xiang, W., Littman, D.R & Butcher, E.C. (2005) Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver.  J. Immunol. 174, 277-83.


Grueter, B., Petter, M., Egawa, T., Laule-Kilian, K., Aldrian, C.J., Wuerch, A., Ludwig, Y., Waldschuetz, R., Möröy, T., Taniuchi, I.,  Steimle, V.,  Littman, D.R., & Ehlers, M. (2005)  Runx3   regulates   integrin  αE/CD103 and  CD4 expression during development of CD4-/CD8+ T cells. J. Immunol. 175,1694-1705.


Geissmann, F., Cameron, T.O., Sidobre, S., Briskin, M.L., Kronenberg, M., Dustin, M.L. & Littman, D.R. (2005) CXCR6 mediates the accumulation and survival of CD1d-reactive T cells that patrol liver sinusoids.  PLoS Biology 3(4):e113.  PMID: 15799695


Feik, N., Bilic, I, Tinhofer, J., Unger, B., Littman, D.R., & Ellmeier, W. (2005) Molecular analysis of the function of the double-positive stage-specific CD8 enhancer CIV-3(E8III) during thymocyte development.  J. Immunol. 174, 1513-24.




Nie, Y.,  Waite, J.,  Brewer, F., Sunshine, M.J.,  Littman, D.R.,  & Zou, Y.-R. (2004) The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity.  J. Exp. Med. 200, 1145-56.


Baumann, J.G., Unutmaz, D., Miller, M.D., Breun, S.K.J., Grill, S.M., Mirro, J., Littman, D.R., Rein, A., & KewalRamani, V. (2004) Murine T cells potently restrict human immunodeficiency virus infection.  J. Virol. 78, 12537-47.


Kawakami, Y., Nishimoto, H., Kitaura, J., Madeda-Yamamoto, M., Kato, R.M., Littman, D.R., Rawlings, D.J., & Kawakami, T. (2004) J. Biol. Chem. 279, 47720-25.


Li, Y., Soos, T.J., Li, X., Wu, J., DeGennaro, M., Sun, X., Littman, D.R., Birnbaum, M.J. & Polakiewicz, R.D. (2004) Protein kinase C theta inhibits insulin signaling by phosphorylating IRS1 at Ser (1101).  J. Biol. Chem. 279, 45304-7. 


Kim, J.K., Fillmore, J.J.,  Sunshine, M.J., Albrecht, B., Higashimori, T., Kim,  D.-W., Liu, Z.-X., Soos, T.J., Cline, G., O'Brien, W.R., Littman, D.R., & Shulman, G.I. (2004) PKC-theta knockout mice are protected from fat-induced insulin resistance.  J. Clin. Invest., 114, 823-7.


Eberl, G. & Littman, D.R. (2004) Thymic origin of intestinal αβ T cells revealed by fate mapping of RORγt+ cells.  Science, 305, 248-251. PMID: 15247480


Taniuchi, I. & Littman, D.R. (2004) Epigenetic gene silencing by Runx proteins.  Oncogene 23, 4341-5.


Marsland, B.J., Soos, T.J., Späth, G., Littman, D.R., & Kopf, M. (2004) Protein kinase C-theta is critical for the development of in vivo Th2 but not Th1 responses.  J. Exp. Med., 200, 181-9.


Fonteneau, J.F., Larsson, M., Beignon, A.S., Dasilva, I., Amara, A., Liu, Y.J., Lifson, J., Littman, D.R., & Bhardwaj, N. (2004) Activation of plasmacytoid dendritic cells by HIV induces bystander maturation of myeloid dendritic cells.  J. Virol. 78, 5223-32.


Berg-Brown, N.N., Gronski, M.A., Jones, R.G., Elford, A.R., Odermatt, B., Littman, D.R., & Ohashi, P.S. (2004) PKCθ signals activation versus tolerance in vivo.  J. Exp. Med. 199, 743-752.


Madakamutil, L.T., Gangadharan, D., Christen, U., Lena, C.J., Wang-Zhu, Y., Attinger, A., Ellmeier, W., von Herrath, M.G., Jensen, P., Littman, D.R., & Cheroutre, H.  (2004) CD8αα+ primary effector cells selectively differentiate into memory CD8 T cells. Science 304, 590-3.


Eberl, G., Marmon, S., Sunshine, M.J., Rennert, P.D., Choi, Y., & Littman, D.R. (2004) An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells.  Nature Immunol. 5, 64-73. PMID: 14691482


Taniuchi, I., Ellmeier, W., & Littman, D.R. (2004) The CD4/CD8 Lineage Choice:  New insights into epigenetic regulation during T cell development.  Adv. Immunol.  83, 55-89.




Amara, A. & Littman, D.R.  (2003)  After Hrs with HIV.  J. Cell Biol. 162, 371-5.


Molyneaux, K.A., Zinszner, H., Kunwar, P.S., Schaible, K., Steble, J., Sunshine, M.J., O’Brien, W., Raz, E., Littman, D.R., Wylie, C., & Lehmann, R. (2003) The chemokine SDF1 and its receptor CXCR4 regulate mouse germ cell migration and survival.  Development 130, 4279-4286.


Eberl, G. & Littman, D.R.  (2003)  Role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer’s patches.  Immunol. Rev. 195, 81-90.


Egawa, T., Albrecht, B., Favier, B., Sunshine, M.J., Mirchandani, K., O’Brien, W., Thome, M., & Littman, D.R.  (2003) Requirement for CARMA1 in antigen receptor-induced NF-κB activation and lymphocyte proliferation.  Curr. Biol. 13, 1252-8.


Geissmann, F., Jung, S., & Littman, D.R. (2003) Blood monocytes consist of two principal subsets with distinct migratory properties.  Immunity 19, 71-82.  PMID: 12871640


Huo, Y., Schober, A., Forlow, S.B., Smith, D.F., Hyman, M.C., Jung, S., Littman, D.R., Weber, C., & Ley, K.  (2003)  Circulating activated platelets exacerbate athrosclerosis in apolipoprotein E deficient mice.  Nature Medicine 9, 61-67.


Chalasani, S.H., Baribaud, F., Coughlan, C.M., Sunshine, M.J., Lee, V.M.Y., Doms, R.W., Littman, D.R., & Raper, J.A. (2003) The chemokine SDF-1 promotes the survival of embryonic retinal ganglion cells.  J. Neurosci. 23, 4601-12.


Chalasani, S.H., Sunshine, M.J., Littman, D.R., & Raper, J.A. (2003)  A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding.  J. Neurosci. 23, 1360-71.




Taniuchi, I., Osato, M., Egawa, T., Sunshine, M.J., Bae, S.-C., Komori, T., Ito, Y. & Littman, D.R. (2002) Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.  Cell 111, 621-633. PMID: 12464175


Ohlrogge, W., Haag, F., Lohler, J., Seman, M., Littman, D.R., Killeen, N. & Koch-Nolte, F. (2002) ART2-deficient T cells are resistant to NAD-induced apoptosis.  Mol. Cell. Biol. 22, 7535-42.


Taniuchi, I., Sunshine, J.J., Festenstein, R., & Littman, D.R. (2002) Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation.  Mol. Cell 10, 1083-96. PMID: 12453416


Guo, J., Hawwari, A., Li., H., Sun, Z., Mahanta, S.K., Littman, D.R., Krangel, M.S., & He, Y.-W. (2002)  Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes.  Nature Immunol. 3, 469-476.


Chi, T.H., Wan, M., Zhao, K., Taniuchi, I., Lee, P.P., Akashi, K., Metzger, D., Wilson, C.B., Chambon, P., Littman, D.R. & Crabtree, G.R. (2002)  Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature 418, 195-199.


Winoto, A. and Littman, D.R. (2002) Nuclear hormone receptors in T lymphocytes.  Cell 109, S57-S66.


Bagri, A., Gurney, T., He, X., Zou, Y.R., Littman, D.R., Tessier-Lavigne, M., & Pleasure, S.J. (2002)  The chemokine SDF-1 regulates migration of dentate granule cells.  Development 129, 4249-4260.


Arendt, C.W., Albrecht, B., Soos, T.J., & Littman, D.R. (2002) Protein Kinase C-θ: Signaling from the center of the T-cell synapse.  Curr. Opin. Immunol. 14, 323-330.


Okada, T., Ngo, V.N., Ekland, E.H., Förster, R., Lipp, M., Littman, D.R. & Cyster, J.G. (2002) Chemokine requirements for B cell entry to lymph nodes and Peyer's patches.  J. Exp. Med. 196, 65-75.


Ellmeier, W., Sunshine, M.J., Maschek, R., & Littman, D.R. (2002)  Combinatorial function of cis-regulatory elements in initiation and maintenance of CD8 expression.  Immunity 16, 623-34.


Jung, S., Unutmaz, D., Wong, P., Sano, G.I., De los Santos, K., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., Pamer, E.G., Littman, D.R., and Lang, R. (2002)  In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 17, 211-220.  PMID:  12196292


Keppler, O.T., Welte, F.J., Ngo, T.A., Patton, K.S., Tsou, C., Abbey, N.W., Sharkey, M.E., You, Y., Scarborough, J.D., Ellmeier, W., Littman, D.R., Stevenson, M., Charo, I.F., Herndier, B.G., Speck, R.F., & Goldsmith, M.A. (2002)  Progress toward a human CD4/CCR5-transgenic rat model for de novo infection by Human Immunodeficiency Virus Type 1.  J. Exp. Med. 195, 719-36.


Harmsen, A., Kusser, K., Hartson, L., Tighe, M., Sunshine, M.J, Sedgwick, J.D., Choi, Y., Littman, D.R. & Randall, T.D. (2002) Organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-α (LTα) and retinoic acid receptor-related orphan receptor-γ, but the organization of NALT is LTα dependent. J. Immunol. 168, 986-990.


Kwon, D.S, Gregario, G., Bitton, N., Hendrickson, W.A., & Littman, D.R. (2002) DC-SIGN mediated internalization of HIV is required for trans-enhancement of T cell infection.  Immunity 16, 135-44.  PMID: 11825572




Huo, Y., Weber, C., Forlow, S.B., Sperandio, M., Thatte, J., Mack, M., Jung, S., Littman, D.R., Ley, K. (2001) The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium.  J. Clin. Invest. 108, 1307-14.


Palframan, R.T., Jung, S., Cheng, G., Weninger, W., Luo, Y., Dorf, M., Littman, D.R., Rollins, B., Zweerink, H., Rot, A., & von Andrian, U.H. (2001) Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues.  J. Exp. Med. 194, 1361-1374.

140.Arendt, C. W. & Littman, D.R. (2001)  HIV:  Master of the host cell.  Genome Biol. 2(11):reviews 1030.1-1030.4.


Baribaud, F., Pohlmann, S., Sparwasser, S., Kimata, M.T.Y., Choi, Y., Haggarty, B.S., Ahmad, N., Macfarlan, T., Edwards, T., Leslie, G., Arnason, J., Reinhart, T.A., Kimata, J.T., Littman, D.R., Hoxie, J.A. & Doms, R.W. (2001) Functional and antigenic characterization of human, rhesus macaque, pigtail macaque, and murine DC-SIGN.  J. Virol. 75: 10,281-10,289.


Zou, Y.R., Sunshine, M.J., Taniuchi, I., Hatam, F., Killeen, N., & Littman, D.R. (2001) The CD4 gene is epigenetically silenced in T cells committed to the cytotoxic lineage.  Nature Genetics 29, 332-336. PMID: 11687799


Browning, C.M., Smith, M.J.. Clark, N.M., Lane, B.R., Parada, C., Montano, M., KewalRamani, V.N., Littman, D.R., Essex, M., Roeder, R.G., & Markovitz, D.M. (2001) Human GLI-2 is a Tat activation response element-independent Tat cofactor. J. Virol. 75, 2314-2323.


Hargreaves, D.C., Hyman, P.L., Ngo, V.N., Lu, T., Bidgol, A., Suzuki, G., Zou, Y.-R., Littman, D.R., & Cyster, J.G. (2001).  A coordinated change in chemokine responsiveness guides plasma cell movements.  J. Exp. Med. 194, 45-56.


Wolfer, A., Bakker, B., Wilson, A., Ionnidis, V., Littman, D.R., Wilson, C., Held, W., MacDonald, H.R., & Radtke, F. (2001) Tissue specific inactivation of Notch1 in immature thymocytes does not perturb lineage commitment, maturation or survival of CD4+ and CD8+ T cells.  Nature Immunol. 2, 235-241.


Pierani, A., Moran-Rivard, L., Sunshine, M.J., Littman, D.R., Goulding, M., & Jessell, T.M. (2001). Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1.  Neuron 29, 367–384.




Ellmeier, W., Sunshine, M.J., Jung, S., Hatam, F., Xu, Y., Baltimore, D., Mano, H., & Littman, D.R.  (2000).  Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk.  J. Exp. Med. 192, 1611-1624.


Unutmaz, D., Xiang, W., Sunshine, M.J., Campbell, J., Butcher, E. & Littman, D.R.  (2000) The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse.  J. Immunol. 165, 3284-92.


Gu, C., Ma, Y.-C., Benjamin, J., Littman, D.R., Chao, M.V., & Huang, X.-Y. (2000) Apoptotic signaling through the β-adrenergic receptor:  a new Gα effector pathway.  J. Biol. Chem. 275, 20726-20733.


Jung, S., Aliberti, J., Graemmel, P., Sunshine, M.J., Kreutzberg, G.W., Sher, A., & Littman, D.R.  (2000)  Analysis of fractalkine receptor CX3CR1 function by targeted deletion and GFP reporter gene insertion.  Mol. Cell. Biol. 20, 4106-14.


Sun, Z., Unutmaz, D., Zou, Y.R., Sunshine, M.J., Pierani, A., Brenner-Morton, S., Mebius, R.E., & Littman, D.R. (2000) Requirement for RORγ in thymocyte survival and lymphoid organ development.  Science 288, 2369-2373. PMID:  10875923


Geijtenbeek, T.B.H., Kwon, D.S., Torensma, R., van Vliet, S.J., van Duijnhoven, G.C.F., Middel, J., Cornelisen, I.L.M.H.A., Nottet, H.S.L.M., KewalRamani, V.N., Littman, D.R., Figdor, C.G., & van Kooyk, Y.(2000) DC-SIGN, a dendritic cell-specific HIV-1 binding protein that enhances trans-infection of T cells. Cell 100, 587–597.


Sun, Z., Arendt, C.W., Ellmeier, W., Schaeffer, E.M., Sunshine, M.J., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg, P.L., & Littman, D.R.  (2000) PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes.  Nature 404, 402-407.




Littman, D.R., Sun, Z., Unutmaz, D., Sunshine, M.J., Petrie, H.T., & Zou, Y.-R. (1999)  Role of the nuclear hormone receptor RORγ in transcriptional regulation, thymocyte survival, and lymphoid organogenesis.  Cold Spring Harbor Symp. Quant. Biol. 64, 373-381.


Fowell, D.J., Shinkai, K., Liao, X.C., Beebe, A.M., Coffman, R.L., Littman, D.R. & Locksley, R.M.  (1999) Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells.  Immunity 11, 399-409.


Vidal, K., Daniel, C., Hill, M., Littman, D.R., & Allen, P.M. (1999)  Differential requirements for CD4 in TCR-ligand interactions.  J. Immunol. 163, 4811-8.


Jung, S. & Littman, D.R. (1999) Chemokine receptors in lymphoid organ homeostasis.  Curr. Opin. Immunol. 11, 319-25.


Unutmaz, D., KewalRamani, V.N., Marmon, S., & Littman, D.R. (1999)  Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes.  J. Exp. Med. 189, 1735-46.


Schaeffer, E.M., Debnath,J., Yap, G., McVicar, D., Liao, X.C., Littman, D.R., Sher, A., Varmus, H.E., Lenardo, M.J., & Schwartzberg, P.L. (1999) Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284, 638-641.


Shelbourne, P.F., Killeen, N, Hevner, R.F., Johnston, H.M., Tecott, L., Lewandoski, M., Ennis, M., Ramirez, L., Li, X., Iannicola, C., Littman, D.R., & Myers, R.M.  (1999)  A Huntington disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice.  Human Mol. Gen. 8, 763-774.


Morner, A., Bjorndal, A, Albert, J., KewalRamani, V.N., Littman, D.R., Inoue, R., Thorstensson, R., Fenyo, E.M., & Bjorling, E. (1999)  Primary HIV-2 isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in co-receptor usage.  J. Virol. 73, 2343-2349.


Ellmeier, W., Sawada, S., & Littman, D.R. (1999)  The regulation of CD4 and CD8 coreceptor gene expression during T cell development.  Ann. Rev. Immunol. 17, 523-554.


LaCasse, R.A., Follis, K.E., Trahey, M., Scarborough, J.D., Littman, D.R., & Nunberg, J.H. (1999)  Fusion-competent vaccines:  Broad neutralization of primary isolates of HIV.  Science 283, 357-362. 


Kimata, J.T., Gosink, J.J., KewalRamani, V.N., Rudense, L.M., Littman, D.R., & Overbaugh, J. (1999) Coreceptor specificity of temporal variants of Simian Immunodeficiency Virus Mne.  J. Virol. 73, 1655-60.




Garber, M.E., Wei, P., KewalRamani, V.N., Mayall, T.P., Herrmann, C., Rice, A., Littman, D.R. & Jones, K.A. (1998)  The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.  Genes and Dev. 12, 3512-3527.


Zhang, Y., Dragic, T., Cao, Y., Littman, D.R., KewalRamani, V.N., & Moore, J.P.  (1998)  Use of co-receptors other than CCR5 or CXCR4 by adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro.  J. Virol. 72, 9337-9344.


Ellmeier, W., Sunshine, M.J.,  Losos, K., & Littman, D.R. (1998)  Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells.  Immunity 9, 485-496.


Rivière, I., Sunshine, M.J., & Littman, D.R. (1998) Regulation of IL-4 expression by activation of individual alleles.  Immunity 9, 217-228.


Langlois, A.J.,  Desrosiers, R.C., Lewis, M.G., KewalRamani, V.N., Littman, D.R., Zhou, J.Y., Manson, K., Wyand, M.S., Bolognesi, D.P., & Montefiori, D.C.(1998) Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus. J. Virol. 72, 6950-6955.


Cecilia, D., KewalRamani, V.N., O’Leary, J., Volsky, B., Nyambi, P., Burda, S., Xu, S., Littman, D.R., & Zolla-Pazner, S. (1998)  Neutralization profiles of HIV-1 primary isolates in the context of coreceptor usage.  J. Virol 72, 6988-6996.


Unutmaz, D., KewalRamani, V.N., & Littman, D.R. (1998) G-protein coupled receptors in HIV and SIV entry: new perspectives on lentivirus-host interactions and on the utility of animal models.  Sem. Immunol. 10, 225-236.


Littman, D.R. (1998)  Chemokine receptors:  Keys to AIDS pathogenesis?  Cell 93, 677-680.


Michael, N.L., Nelson, J.A.E., KewalRamani, V.N., Chang, G., O’Brien, S.J., Mascola, J.R., Volsky, B., Louder, M., White, G.C., Littman, D.R., Swanstrom, R., & O’Brien, T.R. (1998)  Exclusive and persistent use of the entry co-receptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5Δ32.  J. Virol. 72, 6040-6047.


Hill, C.M., Kwon, D., Jones, M., Davis, C., Marmon, S., Daugherty, J., DeMartino, J., Springer, M., Unutmaz, D. & Littman, D.R. (1998) The amino terminus of human CCR5 is required for its function as a receptor for diverse human and simian immunodeficiency virus envelope glycoproteins.  Virology  248, 357-371.


Zou, Y.R., Kottmann, A., Kuroda, M., Taniuchi, I., & Littman, D.R. (1998) Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development.  Nature 393, 595-599.


Irie, H.Y., Mong, M., Itano, A., Crooks, M.E.C., Littman, D.R., Burakoff, S.J., & Robey, E. (1998)  The cytoplasmic domain of CD8β regulates Lck kinase activation and CD8 T cell development.  J. Immunol. 161, 183-191.


Tscherning, C., Alaeus, A., Fredriksson, R., Björndal, Å., Deng, H.K., Littman, D.R., Fenyo, E.M., & Albert, J. (1998) Differences in chemokine coreceptor usage between genetic subtypes of HIV-1. Virology  241, 181-188.


Trkola, A., Ketas, T., KewalRamani, V.N., Endorf, F., Binley, J.M., Katinger, H., Robinson, J., Littman, D.R., & Moore, J.P. (1998) Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of co-receptor usage.  J. Virol. 72, 1876-1885.




Liao, X.C., Littman, D.R., and Weiss, A. (1997)  Itk and Fyn make independent contributions to T cell activation.  J. Exp. Med. 186, 2069-2073.


Ellmeier, W., Sunshine, M.J.,  Losos, K., Hatam, F. & Littman, D.R. (1997) Identification of an enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells.  Immunity 7, 537-547.


Davis, C.B., Dikic, I., Unutmaz, D., Hill, C.M., Siani, M., Schlessinger, J., & Littman, D.R. (1997) Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5.  J. Exp. Med. 186, 1793-1798.


Scarlatti, G., Tresoldi, E., Björndal, Å., Fredriksson, R., Colognesi, C., Deng, H.K., Malnati, M.S., Plebani, A., Siccardi, A.G., Littman, D.R., Fenyo, E.M., and Lusso, P.  (1997)  In vivo evolution of HIV-1 coreceptor usage and sensitivity to chemokine-mediated suppression.  Nature Med. 3, 1259-1265.


Bachmann, M.F., Littman, D.R., and Liao, X.C.  (1997)  Anti-viral immune responses in Itk-deficient mice.  J. Virol. 71, 7253-7257.


Björndal, Å., Deng, H.K., Jansson, M., Fiore, J.R., Karlsson, A., Albert, J., Littman, D.R., and Fenyö, E.M.  (1997) Co-receptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype. J. Virol, 71, 7478-7487.


Deng, H.K., Unutmaz, D., KewalRamani, V.N., & Littman, D.R. (1997)  Expression cloning of novel receptors used by the simian and human immunodeficiency viruses.  Nature 388, 296-300.


Ranga, U., Woffendin, C., Yang, Z., Xu, L., Verma, S., Littman, D.R., & Nabel, G.J. (1997) Cell and viral regulatory elements enhance the expression and function of an HIV inhibitory gene.  J. Virol. 71, 7020-7029.


Hill, C.M., Deng, H.K., Unutmaz, D., Kewalramani, V., Bastiani, L., Zolla-Pazner, S., and Littman, D.R. (1997) Envelope glycoproteins from HIV-1, HIV-2, and SIV can use human CCR5 as a cofactor for viral entry and make direct CD4-dependent interactions with this chemokine receptor.  J. Virol. 71, 6296-6304.


Liao, X.C., Fournier, S., Killeen, N., Weiss, A., Allison, J., & Littman, D.R. (1997) Itk negatively regulates the CD28-mediated costimulatory signal. J. Exp. Med. 186, 221-228.


Unutmaz, D., and Littman, D.R. (1997) Expression pattern of HIV-1 co-receptors on T cells: implications for viral transmission and lymphocyte homing.  Proc. Nat. Acad. Sci. USA.  94, 1615-1618.


Teh, S.-J., Killeen, N., Tarakhovsky, A., Littman, D.R., and Teh, H.-S. (1997)  CD2 regulates the positive selection and function of antigen-specific CD4-CD8+ T cells. Blood 89, 1308-1318.




Hill, C.M. and D.R. Littman (1996) Natural resistance to HIV? (News and Views) Nature 382,  668-669.


Sutton, R. E. and D.R. Littman (1996) Broad host range of human T-Cell leukemia virus type 1 demonstrated with an improved pseudotyping system.  J. Virol. 70, 7322-7326.


Deng, H.K., Rong, L., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R.E., Hill, C.M., Davis, C.B., Peiper, S.C. Schall, T.J., Littman, D.R., Landau, N.R. (1996)  Identification of a major co-receptor for primary isolates of HIV-1.   Nature 381, 661-666.


Weiss, C.D., Barnett, S.W., Cacalano, N., Killeen, N., Littman, D.R., and White, J.M. (1996) Studies of HIV-1 envelope glycoprotein-mediated fusion using a simple fluorescence assay.  AIDS 10, 241-246.


Williams, O., Tanaka, Y., Bix, M., Murdjeva, M., Littman, D. R., and Kioussis, D. (1996)  Inhibition of thymocyte negative selection by T cell receptor antagonist peptides.  Eur. J. Immunol.  26, 532-538.




Liao, C. and Littman, D. R. (1995)  Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.  Immunity 3, 757-769.


Crooks, M.E.C., Littman, D.R., Carter, R.H., Fearon, D.T., Weiss, A., and Stein, P. H. (1995) CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation.  Mol. Cell. Biol. 15, 6820-6828.


Benkirane, M., Antomarchi, H., Littman, D. R., Hirn, M., Rossi, B. And Devaux, C. (1995) The cytoplasmic tail of CD4 is required for inhibition of HIV-1 replication by antibodies that bind to the Ig CDR3-like region in domain 1 of CD4.  J. Virol. 69, 6904-6910.


Golding, H., Dimitrov, D. S., Manischewitz, J., Broder, C. C., Robinson, J., Fabian, S., Littman, D. R., and Lapham, C. K.  (1995) PMA-induced downmodulation of tailess CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules.  J. Virol.  69, 6140-6148.


Killeen, N. and Littman, D. R. (1995)  The regulation and function of the CD4 coreceptor during T lymphocyte development.  Curr. Top. Microbiol. Immunol., 205, 89-106.


Davis, C.B., and Littman, D.R. (1995)  Disrupted development of thymocytes expressing a transgenic TCR upon CD4 overexpression.  Int. Immunol. 7, 1977-1986.


Killeen, N. and Littman, D. R. (1995) The function of the CD4 coreceptor in the development of T cells.  Intern. Rev. Immunol. 13, 15-27.


Xu, H. and Littman, D.R. (1995) The kinase-dependent function of Lck in T cell activation requires an intact site for tyrosine autophosphorylation.  Ann. N.Y. Acad. Sci. , 766, 99-116.




Littman, D. R., Davis, C. B., Killeen, N., and Xu, H. (1994)  Signal transduction during T cell development.  Adv. Exp. Med. Biol. 365, 63-71.


Rajan, T.V., Nelson, F.K., Killeen, N., Shultz, L.D., Yates, J.A., Bailis, J.M.,   Littman, D.R. and Greiner, D.L. (1994) CD4+ T lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.  Exp. Parasitol. 78, 352-360.


Littman, D. (1994) Not enough sans Nef.  Current Biology 4, 618-620.


Crooks, C., and Littman, D.  (1994)  Disruption of T lymphocyte positive and negative selection in mice lacking the CD8β chain.  Immunity 1, 277-285.


Chu, K., and Littman, D.R.  (1994)  Requirement for kinase activity of CD4-associated p56lck in antibody-triggered T cell signal transduction. J. Biol. Chem.  269, 24095-101.


Sawada, S., Scarborough, J.D., Killeen, N., and Littman, D.R.  (1994)  A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development.  Cell 77, 917-929.


Bendelac, A., Killeen, N., Littman, D.R., & Schwartz, R.H.  (1994)  A subset of CD4+8- and CD4-8- αβTCR+ thymocytes selected by class I MHC molecules on hemopoietic cells.  Science 263, 1774-1778.


Davis, C.B., & Littman, D.R.  (1994)  Thymocyte lineage commitment:  is it instructed or stochastic?  Curr. Op. Immunol.6, 266-272.


Killeen, N., & Littman, D.R.  (1994)  Lymphocyte development in genetically manipulated mice.  Ther. Immunol. 1, 123-133.


Weiss, A., & Littman, D.R.  (1994)  Signal transduction by lymphocyte antigen receptors.  Cell 76, 263-274.




Killeen, N., Davis, C.B., Chu, K., Crooks, M.C., Sawada, S., Scarborough, J.D., Boyd, K.A., Stuart, S.G., Xu, H. & Littman, D.R.  (1993)  CD4 function in thymocyte differentiation and T cell activation.   Phil. Trans. R. Soc. Lond. B. 342, 25-34.


Evans, C.F., Rall, G.F., Killeen, N., Littman, D., & Oldstone, M.B.A.  (1993)  CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus.  J. Immunol. 151, 6259-6264.


Golding, H., Blumenthal, R., Manischewitz, J., Littman, D.R., & Dimitrov, D.S.  (1993)  Cell fusion mediated by interaction of a hybrid CD4.CD8 molecule with the human immunodeficiency virus type 1 envelope glycoprotein does occur after a long lag time.  J. Virol. 67, 6469-6475.


Locksley, R., Reiner, S.L., Hatam, F., Littman, D.R., & Killeen, N.  (1993)  Helper T cells without CD4:  control of Leishmaniasis in CD4-deficient mice.  Science 261, 1448-1451.


Killeen, N., & Littman, D.R.  (1993)  Helper T cell development in the absence of CD4-p56lck association.  Nature 364, 729-732.


Sawada, S., and Littman, D.R.  (1993)  A Heterodimer of HEB and an E12-Related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.  Mol. Cell. Biol. 13, 5620-5628.


Xu, H., & Littman, D.R.  (1993).  A kinase-independent function of lck in potentiating antigen-specific T cell activation.  Cell 74, 633-644. 


Davis, C.B., Killeen, N., Crooks, M.E.C., Raulet, D., & Littman, D.R.  (1993)  Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73, 237-47.


Zingler, K., & Littman, D.R.  (1993)  Truncation of the cytoplasmic domain of the SIV envelope glycoprotein increases env incorporation into particles, fusogenicity, and infectivity.  J. Virol. 67, 2824-2831.


Killeen, N., Sawada, S., & Littman, D.R.  (1993)  Regulated expression of human CD4 rescues T-helper cell development in mice lacking expression of endogenous CD4.  EMBO J. 12, 1547-1553.




van Oers, N.S.C., Garvin, A.M., Cooke, M.P., Davis, C.., Littman, D.R., Perlmutter, R.M., & Teh, H-S.  (1992)  Differential involvement of protein tyrosine kinases p56lck and p59fyn in T cell development. Adv. Exp. Med. Biol. 323, 89-99.


Killeen, N., Stuart, S.G., & Littman, D.R.  (1992)  Development and function of T cells in mice with a disrupted CD2 gene.  EMBO J. 11, 4329-4336.


Killeen, N., Moriarty, A., Teh, H.-S., & Littman, D.R.  (1992)  Requirement for CD8-MHC class I interaction in positive and negative selection of developing T cells.  J. Exp. Med. 176, 89-97.


Pelchen-Matthews, A., Boulet, I., Littman, D.R., Fagard, R., & Marsh, M.  (1992)  The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits.  J. Cell Biol. 117, 279-290.


Landau, N.R., & Littman, D.R.  (1992)  A packaging system for producing murine leukemia virus vectors with variable tropism.  J. Virol. 66, 5110-5113.


van Oers, N.S.C., Garvin, A.M., Davis, C.B., Forbush, K.A., Carlow, D.A., Littman, D.R., Perlmutter, R.M., & Teh, H.-S.  (1992)  Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck.  Eur. J. Immunol. 3, 735-743.


Page, K.A., Stearns, S.M., & Littman, D.R.  (1992)  Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity.  J. Virol. 66, 524-533.




Carel, J.C., Holers, V.M., Chick, W.L., Littman, D., et al.  (1991)  Expression of functional human Epstein-Barr virus C3D receptor ([CR2] CD21) on insulinoma cell line - induction of tumor rejection but not diabetes in syngeneic rats.  Diabetes 40, 809-814.


Teitell, M., Mescher, M.F., Olson, C.A., Littman, D.R., & Kronenberg, M.  (1991)  The thymus leukemia antigen binds human and mouse CD8.  J. Exp. Med. 174, 1131-1138.


Poulin, L., Evans. L.A., Tong, S., Ashley, B., Legg, H., Littman, D.R., & Levy, J.A.  (1991)  Several CD4 domains can play a role in human immunodeficiency virus infection of cells.  J. Virol. 65, 4893-4901.


Sawada, S., & Littman, D.R.  (1991)  Identification and characterization of a T cell specific enhancer adjacent to the murine CD4 gene.  Mol. Cell. Biol. 11, 5506-5515.


Turner, J.M., & Littman, D.R.  (1991)  Function of CD4 and CD8 in T-cell activation and differentiation.  In:  Genetic Approaches to Understanding Cell Activation (J. Mond, A. Weiss, and J. Cambier, eds.)  Raven Press, New York, pp. 181-200. 


Page, K.A., Landau, N.R., & Littman, D.R.  (1991)  Human immunodeficiency virus entry into cells.  In:  Viruses That Affect the Immune System (H. Y. Fan et al., eds.), ASM Press, Washington, D.C., pp. 103-112.


Muller, A.J., Young, J.C., Pendergast, A.-M., Pondel, M., Landau, N.R., Littman, D.R., & Witte, O.N.  (1991)  BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome positive human leukemias.  Mol. Cell. Biol. 11, 1785-1792.


Teh, H.-S., Garvin, A.M., Forbush, K.A., Carlow, D.A., Davis, C.B., Littman, D.R., & Perlmutter, R.M.  (1991)  Participation of CD4 coreceptor molecules in T-cell repertoire selection.  Nature 349, 241-243.


Glaichenhaus, N., Shastri, N., Littman, D.R. & Turner, J.M.  (1991)  Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells.  Cell 64, 511-520.


Jasin, M., Page, K.A., & Littman, D.R.  (1991)  GPI-anchored CD4/Thy-1 chimeric molecules serve as HIV receptors in human, but not mouse, cells and are modulated by gangliosides.  J. Virol. 65, 440-444.


Landau, N.R., Page, K.A., & Littman, D.R.  (1991)  Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range.  J. Virol. 65, 162-169.




Page, K.A., Landau, N.R., & Littman, D.R.  (1990)  Construction and use of an HIV vector for analysis of virus infectivity.  J. Virol. 64, 5270-5276.


Salter, R.D., Benjamin, R.J., Wesley, P.K., Buxton, S.E., Garrett, T., Clayberger, C., Krensky, A.M., Norment, A.M., Littman, D.R. & Parham, P.  (1990)  A binding site for the T cell co-receptor CD8 on the α3 domain of HLA-A2.  Nature 345, 41-46.


Turner, J.M., Brodsky, M.H., Irving, B.A., Levin, S.D., Perlmutter, R.M. & Littman, D.R.  (1990)  Interaction of the unique amino-terminal region of the tyrosine kinase p56lck with the cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.  Cell 60, 755-765.


Brodsky, M.H., Warton, M., Myers, R.M. & Littman, D.R.  (1990)  Analysis of the site in CD4 that binds to the HIV envelope glycoprotein.  J. Immunol. 144, 3078-3086.




Littman, D.R.  (1989)  Molecular mechanism of HIV attachment and entry.  Quatrieme Colloque Des Cent Gardes, 123-138.


Littman, D.R.  (1989)  Role of cell-cell interactions in T cell development and activation.  Curr. Op. Cell Biol. 1, 920-928.


Parham, P., Benjamin, R.J., Chen, B.P., Clayberger, C., Ennis, P.D., Krensky, A.M., Lawlor, D.A., Littman, D.R., Norment, A.M., Orr, H.T., Salter, R.D. & Zemmour, J.  (1989)  Diversity of class I HLA molecules:  functional and evolutionary interactions with T cells.  Cold Spr. Harb. Symp. Quant. Biol. 54, 529-543.


White, J.M., & Littman, D.R.  (1989)  Viral receptors of the immunoglobulin superfamily.   Cell 56, 725-728.


Salter, R.D., Norment, A.M., Chen, B.P., Clayberger, C., Krensky, A.M., Littman, D.R. & Parham, P. (1989) Polymorphism in the α3 domain of HLA-A molecules affects binding to CD8.  Nature 338, 345-347.


Norment, A.M., Lonberg, N., Lacy, E., & Littman, D.R. (1989) An alternatively spliced mRNA encodes a secreted form of human CD8α.  J. Immunol. 142, 3312-3319.




Norment, A.M., Salter, R.D., Parham, P., Engelhard, V. & Littman, D.R. (1988)  Cell-cell adhesion mediated by CD8 and MHC class I molecules.  Nature 336, 79-81.


Norment, A.M. & Littman, D.R. (1988) A second subunit of CD8 is expressed in human T cells.  EMBO J. 7, 3433-3439.


Kaldjian, E., McCarthy, S.A., Sharrow, S.O., Littman, D.R., Klausner, R.D., & Singer, A. (1988) Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression.  FASEB J. 2, 2801-2806.


Bedinger, P., Moriarty, A., von Borstel, R., Donovan, N., Steimer, K., & Littman, D.R. (1988)  Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4. Nature 334, 162-165.


Landau, N.R., Warton, M., & Littman, D.R. (1988)  The envelope glycoprotein  of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4.  Nature 334, 159-162.


Newgard, C.B., Littman, D.R., van Genderen, C., Smith, M. & Fletterick, R.J. (1988) Human brain glycogen phosphorylase: cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes. J. Biol. Chem. 263, 3850-3857.


Lonberg, N., Gettner, S., Lacy, E. & Littman, D. (1988) Mouse brain CD4 transcripts encode only the COOH-terminal half of the protein.  Mol. Cell. Biol. 8, 2224-2228.


Subar, M., Pelicci, P.G., Neri, A., Allavena, P., Littman, D.R., Knowles, D.M. 2d & Dalla-Favera, R. (1988) Patterns of T cell receptor gamma gene rearrangement and expression in B and T lymphoid malignancies.  Leukemia 2, 19-26.




Pelicci, P.G., Neri, A., Knowles, D. M., Littman, D. R., Dalla-Favera, R. & Subar, M. (1987) Arrangements and rearrangements of the human T-cell receptor gamma gene. Annals N.Y. Acad. Sci. 511, 232-245.


Loh, E.Y., Lanier, L.L., Turck, C.W., Littman, D.R., Davis, M.M., Chien, Y.H., & Weiss, A. (1987) Identification and sequence of a fourth human T cell antigen receptor chain. Nature 330, 569-572.


Pelicci, P.G., Subar, M., Weiss, A., Dalla-Favera, R., & Littman, D.R.  (1987) Molecular diversity of the human T-gamma constant region genes.  Science 237, 1051-1055.


Hashimoto, Y., Yui, K., Littman, D., & Greene, M. I. (1987) T-cell receptor genes in autoimmune mice: T-cell subsets have unexpected T-cell receptor gene programs. Proc. Nat. Acad. Sci. USA 84, 5883-5887.


Lanier, L. L., Federspiel, N.A., Ruitenberg, J.J., Phillips, J.H., Allison, J.P., Littman, D.R., & Weiss, A. (1987) The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes: A CD3-associated disulfide-linked γ chain heterodimer.  J. Exp. Med. 165, 1076-1094.


Littman, D.R. (1987) Structure and potential function of the murine L3T4 molecule.  Ann. Inst. Pasteur 138, 147-150.


Littman, D.R. and Chao, M. V. (1987) Use of gene transfer in the isolation of cell surface receptor genes.  In: Genetic Engineering, Principles and Methods (Setlow, J.K., ed.), Plenum Press, New York, Vol. 9, pp. 89-103.


Littman, D.R. (1987) The structure of the CD4 and CD8 genes. Ann. Rev. Immunol. 5, 561-584.


Littman, D., Newton, M., Crommie, D., Seidman, J.G., Gettner, S. & Weiss, A. (1987) Characterization of an expressed CD3-associated Tiγ chain reveals C-region polymorphism. Nature 326, 85-88.


Littman, D.R. & Gettner, S. (1987) Unusual intron in Ig domain of newly isolated murine CD4 (L3T4) gene.  Nature 325, 453-455.




McDougal, J.S., Maddon, P.J.,  Dalgleish, A.G., Clapham, P.R., Littman, D.R., Godfrey, M., Maddon, D.E., Chess, L., Weiss, R.A., & Axel, R. (1986) The T4 glycoprotein is a cell-surface receptor for the AIDS virus.  Cold Spring Harb Symp Quant Biol 51 Pt 2: 703-11.


Isobe, M., Huebner, K., Maddon, P.J., Littman, D.R., Axel, R., & Croce, C.M. (1986) The gene encoding the T cell surface protein T4 is located on human chromosome 12. Proc. Nat. Acad. Sci. USA 83, 4399-4402.




Maddon, P., Littman, D.R., Godfrey, M., Maddon, D., Chess, L. & Axel, R. (1985) The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell 42, 93-104.


Littman, D.R., Thomas, Y., Maddon, P., Chess, L. & Axel, R. (1985) The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. Cell 40, 237-246.




Cullen, S.E., Kindle, C.S., & Littman, D.R. (1979) Structural comparison of murine Ia antigens determined by the I-A and I-E subregions. J. Immunol. 122, 855-859.


Littman, D.R., Cullen, S.E., & Schwartz, B.D. (1979) Insertion of Ia and H-2 antigens into model membranes. Proc. Nat. Acad. Sci. USA 76, 902-906.




Santala, R., Gottlieb, D.I., Littman, D.R., & Glaser, L. (1977)  Selective cell adhesion of neuronal cell lines. J. Biol. Chem. 252, 7625-7634.




Glaser, L., Merrell, R., Gottlieb, D.I., Littman, D., Pulliam, M.W., & Bradshaw, R.A. (1976) Neuronal cell adhesion. In: Surface membrane receptors (R.A. Bradshaw et al., eds.) Plenum Press, New York, p. 109-131.




Kirschner, M.W., Suter, M.M., Weingarten, M., & Littman, D.R. (1975)  The role of rings in the assembly of microtubules in vitro.  Ann. N.Y. Acad. Sci. 253, 90-106.




Weingarten, M.D., Suter, M.M., Littman, D.R. & Kirschner, M.W. (1974)   Properties of the depolymerization products of microtubules from mammalian brain.  Biochemistry 13, 5529-5537.