Immunology Journal Club Papers

December 11, 2018

Stela Sota

Proto JD, Doran AC, Gusarova G, Yurdagul A Jr, Sozen E, Subramanian M, Islam MN, Rymond CC, Du J, Hook J, Kuriakose G, Bhattacharya J, Tabas I. Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity. 2018 Oct 16;49(4):666-677.e6. doi: 10.1016/j.immuni.2018.07.015. Epub 2018 Oct 2. PubMed PMID: 30291029; PubMed Central PMCID: PMC6192849.

Frank Yeung

Shimada K, Porritt RA, Markman JL, O'Rourke JG, Wakita D, Noval Rivas M, Ogawa C, Kozhaya L, Martins GA, Unutmaz D, Baloh RH, Crother TR, Chen S, Arditi M. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018 Nov 20;49(5):873-885.e7. doi: 10.1016/j.immuni.2018.08.022. Epub 2018 Oct 23. PubMed PMID: 30366765; PubMed Central PMCID: PMC6260980.

December 4, 2018

Dhaval Dixit

Yao Y, Jeyanathan M, Haddadi S, Barra NG, Vaseghi-Shanjani M, Damjanovic D, Lai R, Afkhami S, Chen Y, Dvorkin-Gheva A, Robbins CS, Schertzer JD, Xing Z. Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity. Cell. 2018 Oct 20. pii: S0092-8674(18)31254-6. doi:10.1016/j.cell.2018.09.042. [Epub ahead of print] PubMed PMID: 30433869.

Lee Serpas

Michelet X, Dyck L, Hogan A, Loftus RM, Duquette D, Wei K, Beyaz S, Tavakkoli A, Foley C, Donnelly R, O'Farrelly C, Raverdeau M, Vernon A, Pettee W, O'Shea D, Nikolajczyk BS, Mills KHG, Brenner MB, Finlay D, Lynch L. Metabolic reprogramming of natural killer cells in obesity limits antitumor responses. Nat Immunol. 2018 Dec;19(12):1330-1340. doi: 10.1038/s41590-018-0251-7. Epub 2018 Nov 12. PubMed PMID: 30420624.

November 27, 2018

Oriana Perez (Reizis lab)

Fatkhullina AR, Peshkova IO, Dzutsev A, Aghayev T, McCulloch JA, Thovarai V, Badger JH, Vats R, Sundd P, Tang HY, Kossenkov AV, Hazen SL, Trinchieri G, Grivennikov SI, Koltsova EK. An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis. Immunity. 2018 Oct 25. pii: S1074-7613(18)30426-6. doi: 10.1016/j.immuni.2018.09.011. [Epub ahead of print] PubMed PMID: 30389414.

Varsha Raghavan (Littman lab)

Zeng Z, Surewaard BGJ, Wong CHY, Guettler C, Petri B, Burkhard R, Wyss M, Le Moual H, Devinney R, Thompson GC, Blackwood J, Joffe AR, McCoy KD, Jenne CN, Kubes P. Sex-hormone-driven innate antibodies protect females and infants against EPEC infection. Nat Immunol. 2018 Oct;19(10):1100-1111. doi: 10.1038/s41590-018-0211-2. Epub 2018 Sep 24. PubMed PMID: 30250184.

November 20, 2018

Jhimmy Talbot (Littman lab)

Theisen DJ, Davidson JT 4th, Briseño CG, Gargaro M, Lauron EJ, Wang Q, Desai P, Durai V, Bagadia P, Brickner JR, Beatty WL, Virgin HW, Gillanders WE, Mosammaparast N, Diamond MS, Sibley LD, Yokoyama W, Schreiber RD, Murphy TL, Murphy KM. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Science. 2018 Nov 9;362(6415):694-699. doi: 10.1126/science.aat5030. PubMed PMID: 30409884.

November 13, 2018

P’ng Loke

Choi HW, Suwanpradid J, Kim IH, Staats HF, Haniffa M, MacLeod AS, Abraham SN. Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. Science. 2018 Nov 9;362(6415). pii: eaao0666. doi: 10.1126/science.aao0666. PubMed PMID: 30409859.

Tariq Najar (Littman lab)

Lu Y, Wang Q, Xue G, Bi E, Ma X, Wang A, Qian J, Dong C, Yi Q. Th9 Cells Represent a Unique Subset of CD4(+) T Cells Endowed with the Ability to Eradicate Advanced Tumors. Cancer Cell. 2018 Jun 11;33(6):1048-1060.e7. doi: 10.1016/j.ccell.2018.05.004. PubMed PMID: 29894691; PubMed Central PMCID: PMC6072282.

November 6, 2018

Hernandez Moura Silva (Juan Lafaille lab)

Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ. T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation. Cell. 2018 Oct 26. pii: S0092-8674(18)31316-3. doi: 10.1016/j.cell.2018.10.008. [Epub ahead of print] PubMed PMID: 30392957.

Katharine Lu Yang (Koralov lab)

Chongsathidkiet P, Jackson C, Koyama S, Loebel F, Cui X, Farber SH, Woroniecka K, Elsamadicy AA, Dechant CA, Kemeny HR, Sanchez-Perez L, Cheema TA, Souders NC, Herndon JE, Coumans JV, Everitt JI, Nahed BV, Sampson JH, Gunn MD, Martuza RL, Dranoff G, Curry WT, Fecci PE. Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. Nat Med. 2018 Sep;24(9):1459-1468. doi: 10.1038/s41591-018-0135-2. Epub 2018 Aug 13. PubMed PMID: 30104766; PubMed Central PMCID: PMC6129206.

October 30, 2018

Joe Pucella (Reizis lab)

Marcus A, Mao AJ, Lensink-Vasan M, Wang L, Vance RE, Raulet DH. Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response. Immunity. 2018 Oct 16;49(4):754-763.e4. doi: 10.1016/j.immuni.2018.09.016. PubMed PMID: 30332631.

Doua Azzouz (Silverman lab)

Cho H, Jaime H, de Oliveira RP, Kang B, Spolski R, Vaziri T, Myers TG, Thovarai V, Shen Z, Fox JG, Leonard WJ, Kelsall BL. Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity. Mucosal Immunol. 2018 Aug 7. doi: 10.1038/s41385-018-0056-x. [Epub ahead of print] PubMed PMID: 30087442.

October 23, 2018

Patrícia d’Emery (Juan Lafaille lab)

Cunha LD, Yang M, Carter R, Guy C, Harris L, Crawford JC, Quarato G, Boada-Romero E, Kalkavan H, Johnson MDL, Natarajan S, Turnis ME, Finkelstein D, Opferman JT, Gawad C, Green DR. LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance. Cell. 2018 Oct 4;175(2):429-441.e16. doi: 10.1016/j.cell.2018.08.061. Epub 2018 Sep 20. PubMed PMID: 30245008; PubMed Central PMCID: PMC6201245.

Shruti Naik

Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH 2nd, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature. 2018 Aug; 560(7720):649-654. doi: 10.1038/s41586-018-0449-8. Epub 2018 Aug 22. PubMed PMID: 30135581; PubMed Central PMCID: PMC6133715.

October 16, 2018

Ranit Kedmi (Littman lab)

Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Küttner V, Bružas E, Maiorino L, Bautista C, Carmona EM, Gimotty PA, Fearon DT, Chang K, Lyons SK, Pinkerton KE, Trotman LC, Goldberg MS, Yeh JT, Egeblad M. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. 2018 Sep 28;361(6409). pii: eaao4227. doi: 10.1126/science.aao4227. PubMed PMID: 30262472.

Margaret Warren (Reizis lab)

Holz LE, Prier JE, Freestone D, Steiner TM, English K, Johnson DN, Mollard V, Cozijnsen A, Davey GM, Godfrey DI, Yui K, Mackay LK, Lahoud MH, Caminschi I, McFadden GI, Bertolino P, Fernandez-Ruiz D, Heath WR. CD8(+) T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver. Cell Rep. 2018 Oct 2;25(1):68-79.e4. doi: 10.1016/j.celrep.2018.08.094. PubMed PMID: 30282039.

October 2, 2018

Yu Matsuzawa (Cadwell lab)

Dijkstra KK, Cattaneo CM, Weeber F, Chalabi M, van de Haar J, Fanchi LF, Slagter M, van der Velden DL, Kaing S, Kelderman S, van Rooij N, van Leerdam ME, Depla A, Smit EF, Hartemink KJ, de Groot R, Wolkers MC, Sachs N, Snaebjornsson P, Monkhorst K, Haanen J, Clevers H, Schumacher TN, Voest EE. Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids. Cell. 2018 Sep 6;174(6):1586-1598.e12. doi: 10.1016/j.cell.2018.07.009. Epub 2018 Aug 9. PubMed PMID: 30100188.

Raquel Arifa (Juan Lafaille lab)

Bauché D, Joyce-Shaikh B, Jain R, Grein J, Ku KS, Blumenschein WM, Ganal-Vonarburg SC, Wilson DC, McClanahan TK, Malefyt RW, Macpherson AJ, Annamalai L, Yearley JH, Cua DJ. LAG3(+) Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis. Immunity. 2018 Aug 21;49(2):342-352.e5. doi: 10.1016/j.immuni.2018.07.007. Epub 2018 Aug 7. PubMed PMID: 30097293.

September 25, 2018

Ioanna Tiniakou (Reizis lab)

Lian H, Zang R, Wei J, Ye W, Hu MM, Chen YD, Zhang XN, Guo Y, Lei CQ, Yang Q, Luo WW, Li S, Shu HB. The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors. Immunity. 2018 Sep 18;49(3):438-448.e5. doi: 10.1016/j.immuni.2018.08.014. Epub 2018 Sep 4. PubMed PMID: 30193849.

Axel Concepcion (Feske lab)

Shi J, Hou S, Fang Q, Liu X, Liu X, Qi H. PD-1 Controls Follicular T Helper Cell Positioning and Function. Immunity. 2018 Aug 21;49(2):264-274.e4. doi: 10.1016/j.immuni.2018.06.012. Epub 2018 Jul 31. PubMed PMID: 30076099; PubMed Central PMCID: PMC6104813.

September 18, 2018

Matt Keller (Cadwell lab)

Sollberger G, Choidas A, Burn GL, Habenberger P, Di Lucrezia R, Kordes S, Menninger S, Eickhoff J, Nussbaumer P, Klebl B, Krüger R, Herzig A, Zychlinsky A. Gasdermin D plays a vital role in the generation of neutrophil extracellular traps. Sci Immunol. 2018 Aug 24;3(26). pii: eaar6689. doi: 10.1126/sciimmunol.aar6689. PubMed PMID: 30143555.

September 11, 2018

Carlos Aranda (Maria Lafaille)

Takatsuka S, Yamada H, Haniuda K, Saruwatari H, Ichihashi M, Renauld JC, Kitamura D. IL-9 receptor signaling in memory B cells regulates humoral recall responses. Nat Immunol. 2018 Sep;19(9):1025-1034. doi: 10.1038/s41590-018-0177-0. Epub 2018 Aug 6. PubMed PMID: 30082831.

Mo Xu (Littman)

Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Parkin and PINK1 mitigate STING-induced inflammation. Nature. 2018 Aug 22. doi: 10.1038/s41586-018-0448-9. [Epub ahead of print] PubMed PMID: 30135585.

September 4, 2018

Jessica Neil (Cadwell lab)

Metidji A, Omenetti S, Crotta S, Li Y, Nye E, Ross E, Li V, Maradana MR, Schiering C, Stockinger B. The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity. Immunity. 2018 Aug 21;49(2):353-362.e5. doi: 10.1016/j.immuni.2018.07.010. Epub 2018 Aug 14. PubMed PMID: 30119997; PubMed Central PMCID: PMC6104739.

Boris Reizis

Gavin AL, Huang D, Huber C, Mårtensson A, Tardif V, Skog PD, Blane TR, Thinnes TC, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, Schulz SR, Zarpellon A, Cravatt B, Pang ES, Teijaro J, de la Torre JC, O'Keeffe M, Hochrein H, Damme M, Teyton L, Lawson BR, Nemazee D. PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing. Nat Immunol. 2018 Sep;19(9):942-953. doi: 10.1038/s41590-018-0179-y. Epub 2018 Aug 13. PubMed PMID: 30111894; PubMed Central PMCID: PMC6105523.

August 21, 2018

Hannah Fehlner-Peach (Littman lab)

Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW. Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition. Nature. 2018 Aug;560(7719):489-493. doi: 10.1038/s41586-018-0395-5. Epub 2018 Aug 8. PubMed PMID: 30089902.

Sascha Kahlfuss (Feske lab)

Chen G, Zuo S, Tang J, Zuo C, Jia D, Liu Q, Liu G, Zhu Q, Wang Y, Zhang J, Shen Y, Chen D, Yuan P, Qin Z, Ruan C, Ye J, Wang XJ, Zhou Y, Gao P, Zhang P, Liu J, Jing ZC, Lu A, Yu Y. Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice. J Exp Med. 2018 Aug 6;215(8):2175-2195. doi: 10.1084/jem.20171767. Epub 2018 Jul 3. PubMed PMID: 29970474; PubMed Central PMCID: PMC6080901.

August 14, 2018

Ali Rashidfarrokhi (Reizis lab)

Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 Jul 25. doi: 10.1038/s41586-018-0372-z. [Epub ahead of print] PubMed PMID: 30046112.

Audrey Baeyens (Schwab lab)

Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD; National Heart, Lung, and Blood Institute Severe Asthma Research Program-3 Investigators. Neutrophil cytoplasts induce T(H)17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018 Aug 3;3(26). pii: eaao4747. doi: 10.1126/sciimmunol.aao4747. PubMed PMID: 30076281.

August 7, 2018

Kai Mesa (Littman Lab)

Russo MV, Latour LL, McGavern DB. Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury. Nat Immunol. 2018 May;19(5):442-452. doi: 10.1038/s41590-018-0086-2. Epub 2018 Apr 16. PubMed PMID: 29662169.

July 31, 2018

June-Yong Lee (Littman Lab)

Borges da Silva H, Beura LK, Wang H, Hanse EA, Gore R, Scott MC, Walsh DA, Block KE, Fonseca R, Yan Y, Hippen KL, Blazar BR, Masopust D, Kelekar A, Vulchanova L, Hogquist KA, Jameson SC. The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8(+) T cells. Nature. 2018 Jul;559(7713):264-268. doi: 10.1038/s41586-018-0282-0. Epub 2018 Jul 4. PubMed PMID: 29973721; PubMed Central PMCID: PMC6054485.

July 24, 2018

Eugene Rudensky (Cadwell Lab)

Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS. Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development. Nature. 2018 Jul;559(7715):627-631. doi: 10.1038/s41586-018-0345-2. Epub 2018 Jul 18. PubMed PMID: 30022164; PubMed Central PMCID: PMC6062473.

July 17, 2018

Lin Wu (Littman Lab)

Bunse L, Pusch S, Bunse T, Sahm F, Sanghvi K, Friedrich M, Alansary D, Sonner JK, Green E, Deumelandt K, Kilian M, Neftel C, Uhlig S, Kessler T, von Landenberg A, Berghoff AS, Marsh K, Steadman M, Zhu D, Nicolay B, Wiestler B, Breckwoldt MO, Al-Ali R, Karcher-Bausch S, Bozza M, Oezen I, Kramer M, Meyer J, Habel A, Eisel J, Poschet G, Weller M, Preusser M, Nadji-Ohl M, Thon N, Burger MC, Harter PN, Ratliff M, Harbottle R, Benner A, Schrimpf D, Okun J, Herold-Mende C, Turcan S, Kaulfuss S, Hess-Stumpp H, Bieback K, Cahill DP, Plate KH, Hänggi D, Dorsch M, Suvà ML, Niemeyer BA, von Deimling A, Wick W, Platten M. Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. Nat Med. 2018 Jul 9. doi: 10.1038/s41591-018-0095-6. [Epub ahead of print] PubMed PMID: 29988124.

Ludovic Desvignes

Ben-Shaanan TL, Schiller M, Azulay-Debby H, Korin B, Boshnak N, Koren T, Krot M, Shakya J, Rahat MA, Hakim F, Rolls A. Modulation of anti-tumor immunity by the brain's reward system. Nat Commun. 2018 Jul 13;9(1):2723. doi: 10.1038/s41467-018-05283-5. PubMed PMID: 30006573; PubMed Central PMCID: PMC6045610.

July 10, 2018

Sean Saunders (Maria Lafaille Lab)

Halim TYF, Rana BMJ, Walker JA, Kerscher B, Knolle MD, Jolin HE, Serrao EM, Haim-Vilmovsky L, Teichmann SA, Rodewald HR, Botto M, Vyse TJ, Fallon PG, Li Z, Withers DR, McKenzie ANJ. Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells. Immunity. 2018 Jun 19;48(6):1195-1207.e6. doi: 10.1016/j.immuni.2018.05.003. Epub 2018 Jun 12. PubMed PMID: 29907525; PubMed Central PMCID: PMC6015114.

Patty Martin (Cadwell Lab)

Du M, Chen ZJ. DNA-induced liquid phase condensation of cGAS activates innate immune signaling. Science. 2018 Jul 5. pii: eaat1022. doi: 10.1126/science.aat1022. [Epub ahead of print] PubMed PMID: 29976794.

July 3, 2018

Tomasz Kurcon (Littman Lab)

Shepherd ES, DeLoache WC, Pruss KM, Whitaker WR, Sonnenburg JL. An exclusive metabolic niche enables strain engraftment in the gut microbiota. Nature. 2018 May;557(7705):434-438. doi: 10.1038/s41586-018-0092-4. Epub 2018 May 9. PubMed PMID: 29743671.

Maria Lafaille

Tsui C, Martinez-Martin N, Gaya M, Maldonado P, Llorian M, Legrave NM, Rossi M, MacRae JI, Cameron AJ, Parker PJ, Leitges M, Bruckbauer A, Batista FD. Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis. Immunity. 2018 Jun 19;48(6):1144-1159.e5. doi: 10.1016/j.immuni.2018.04.031. Epub 2018 Jun 5. PubMed PMID: 29884460; PubMed Central PMCID: PMC6015119.

June 26, 2018

Jason Hall (Littman Lab)

Degirmenci B, Valenta T, Dimitrieva S, Hausmann G, Basler K. GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells. Nature. 2018 Jun 6. doi: 10.1038/s41586-018-0190-3. [Epub ahead of print] PubMed PMID: 29875413.

Susan Schwab

Polonsky M, Rimer J, Kern-Perets A, Zaretsky I, Miller S, Bornstein C, David E, Kopelman NM, Stelzer G, Porat Z, Chain B, Friedman N. Induction of CD4 T cell memory by local cellular collectivity. Science. 2018 Jun 15;360(6394). pii: eaaj1853. doi: 10.1126/science.aaj1853. PubMed PMID: 29903938.

June 19, 2018

Ken Cadwell

Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM. A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Cell. 2018 May 23. pii: S0092-8674(18)30591-9. doi: 10.1016/j.cell.2018.05.014. [Epub ahead of print] PubMed PMID: 29887373.

Varsha Raghavan (Littman Lab)

Trompette A, Gollwitzer ES, Pattaroni C, Lopez-Mejia IC, Riva E, Pernot J, Ubags N, Fajas L, Nicod LP, Marsland BJ. Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling MonocyteHematopoiesis and CD8+ T Cell Metabolism. Immunity. 2018 May 15;48(5):992-1005.e8. doi: 10.1016/j.immuni.2018.04.022.

June 12, 2018

Hao Xu (Littman Lab)

Du X, Wen J, Wang Y, Karmaus PWF, Khatamian A, Tan H, Li Y, Guy C, Nguyen TM, Dhungana Y, Neale G, Peng J, Yu J, Chi H. Hippo/Mst signalling couples metabolic state and immune function of CD8α(+) dendritic cells. Nature. 2018 Jun; 558(7708):141-145. doi: 10.1038/s41586-018-0177-0. Epub 2018 May 30. PubMed PMID: 29849151.

Jhimmy Talbot (Littman Lab)

Ma C, Han M, Heinrich B, Fu Q, Zhang Q, Sandhu M, Agdashian D, Terabe M, Berzofsky JA, Fako V, Ritz T, Longerich T, Theriot CM, McCulloch JA, Roy S, Yuan W, Thovarai V, Sen SK, Ruchirawat M, Korangy F, Wang XW, Trinchieri G, Greten TF. Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Science. 2018 May 25;360(6391). pii: eaan5931. doi: 10.1126/science.aan5931. PubMed PMID: 29798856.

June 5, 2018

Oriana Perez (Reizis Lab)

Shinde R, Hezaveh K, Halaby MJ, Kloetgen A, Chakravarthy A, da Silva Medina T, Deol R, Manion KP, Baglaenko Y, Eldh M, Lamorte S, Wallace D, Chodisetti SB, Ravishankar B, Liu H, Chaudhary K, Munn DH, Tsirigos A, Madaio M, Gabrielsson S, Touma Z, Wither J, De Carvalho DD, McGaha TL. Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans. Nat Immunol. 2018 Jun;19(6):571-582. doi: 10.1038/s41590-018-0107-1. Epub 2018 May 14. PubMed PMID: 29760532; PubMed Central PMCID: PMC5976527.

May 29, 2018

Anastasia Zavitsanou

Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. PubMed PMID: 29590092.

Tariq Najar (Littman Lab)

Gee MH, Han A, Lofgren SM, Beausang JF, Mendoza JL, Birnbaum ME, Bethune MT, Fischer S, Yang X, Gomez-Eerland R, Bingham DB, Sibener LV, Fernandes RA, Velasco A, Baltimore D, Schumacher TN, Khatri P, Quake SR, Davis MM, Garcia KC. Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes. Cell. 2018 Jan 25;172(3):549-563.e16. doi: 10.1016/j.cell.2017.11.043. Epub 2017 Dec 21. PubMed PMID: 29275860; PubMed Central PMCID: PMC5786495.

May 22, 2018

P’ng Loke

Link VM, Duttke SH, Chun HB, Holtman IR, Westin E, Hoeksema MA, Abe Y, Skola D, Romanoski CE, Tao J, Fonseca GJ, Troutman TD, Spann NJ, Strid T, Sakai M, Yu M, Hu R, Fang R, Metzler D, Ren B, Glass CK. Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function. Cell. 2018 May 5. pii: S0092-8674(18)30511-7. doi:10.1016/j.cell.2018.04.018. [Epub ahead of print] PubMed PMID: 29779944.

Hernandez Moura Silva (Lafaille Lab)

Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, de Lima KA, Gutiérrez-Vázquez C, Hewson P, Staszewski O, Blain M, Healy L, Neziraj T, Borio M, Wheeler M, Dragin LL, Laplaud DA, Antel J, Alvarez JI, Prinz M, Quintana FJ. Microglial control of astrocytes in response to microbial metabolites. Nature. 2018 May;557(7707):724-728. doi: 10.1038/s41586-018-0119-x. Epub 2018 May 16. PubMed PMID: 29769726.

May 15, 2018

Katharine Lu Yang (Koralov lab)

Donaldson GP, Ladinsky MS, Yu KB, Sanders JG, Yoo BB, Chou WC, Conner ME, Earl AM, Knight R, Bjorkman PJ, Mazmanian SK. Gut microbiota utilize immunoglobulin A for mucosal colonization. Science. 2018 May 3. pii: eaaq0926. doi: 10.1126/science.aaq0926. [Epub ahead of print] PubMed PMID: 29724905.

May 8, 2018

Stephen Yeung (Khanna Lab)

Cronk JC, Filiano AJ, Louveau A, Marin I, Marsh R, Ji E, Goldman DH, Smirnov I, Geraci N, Acton S, Overall CC, Kipnis J. Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia. J Exp Med. 2018 Apr 11. pii: jem.20180247. doi: 10.1084/jem.20180247. [Epub ahead of print] PubMed PMID: 29643186.

Denis Loredan

Wilson AM, Shao Z, Grenier V, Mawambo G, Daudelin JF, Dejda A, Pilon F, Popovic N, Boulet S, Parinot C, Oubaha M, Labrecque N, de Guire V, Laplante M, Lettre G, Sennlaub F, Joyal JS, Meunier M, Sapieha P. Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome. Sci Immunol. 2018 Mar 16;3(21). pii: eaan4626. doi: 10.1126/sciimmunol.aan4626. PubMed PMID: 29549139.

May 1, 2018

Geunhyo Jang

Xia P, Wang S, Ye B, Du Y, Li C, Xiong Z, Qu Y, Fan Z. A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion. Immunity. 2018 Apr 17;48(4):688-701.e7. doi: 10.1016/j.immuni.2018.03.016. Epub 2018 Apr 3. PubMed PMID: 29625897.

Alice Kwon (Littman and Liddelow Labs)

Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, Skodras A, Blank T, Staszewski O, Datta M, Centeno TP, Capece V, Islam MR, Kerimoglu C, Staufenbiel M, Schultze JL, Beyer M, Prinz M, Jucker M, Fischer A, Neher JJ. Innate immune memory in the brain shapes neurological disease hallmarks. Nature. 2018 Apr;556(7701):332-338. doi: 10.1038/s41586-018-0023-4. Epub 2018 Apr 11. PubMed PMID: 29643512.

April 24, 2018

Doua Azzouz (Silverman Lab)

Mohammad I, Starskaia I, Nagy T, Guo J, Yatkin E, Väänänen K, Watford WT, Chen Z. Estrogen receptor α contributes to T cell-mediated autoimmune inflammation by promoting T cell activation and proliferation. Sci Signal. 2018 Apr 17;11(526). pii: eaap9415. doi: 10.1126/scisignal.aap9415. PubMed PMID: 29666308.

Priya Issuree (Littman Lab)

Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW. Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science. 2018 Apr 13;360(6385):204-208. doi:10.1126/science.aar3799. PubMed PMID: 29650672.

April 17, 2018

Gavyn Bee

Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 May;24(4):417-426. doi: 10.1038/nm.4501. Epub 2018 Mar 5. PubMed PMID: 29505031.

Cristina Castro-Rivera

Jin L, Guo X, Shen C, Hao X, Sun P, Li P, Xu T, Hu C, Rose O, Zhou H, Yang M, Qin CF, Guo J, Peng H, Zhu M, Cheng G, Qi X, Lai R. Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor. Nat Immunol. 2018 Apr;19(4):342-353. doi: 10.1038/s41590-018-0063-9. Epub 2018 Mar 5. PubMed PMID: 29507355.

April 10, 2018

Erica Ma

Li X, Gadzinsky A, Gong L, Tong H, Calderon V, Li Y, Kitamura D, Klein U, Langdon WY, Hou F, Zou YR, Gu H. Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction. Immunity. 2018 Mar 20;48(3):530-541.e6. doi: 10.1016/ j.immuni. 2018. 03. 006. PubMed PMID: 29562201.

Felicia Kuperwaser

Kim JH, Podstawka J, Lou Y, Li L, Lee EKS, Divangahi M, Petri B, Jirik FR, Kelly MM, Yipp BG. Aged polymorphonuclear leukocytes cause fibrotic interstitial lung disease in the absence of regulation by B cells. Nat Immunol. 2018 Feb;19(2):192-201. doi: 10.1038/s41590-017-0030-x. Epub 2018 Jan 15. PubMed PMID: 29335647.

April 3, 2018

Margaret Kirkling (Reizis Lab)

Böttcher JP, Bonavita E, Chakravarty P, Blees H, Cabeza-Cabrerizo M, Sammicheli S, Rogers NC, Sahai E, Zelenay S, Reis E Sousa C. NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control. Cell. 2018 Feb 22; 172(5): 1022-1037.e14. doi: 10.1016/j.cell.2018.01.004. Epub 2018 Feb 8. PubMed PMID: 29429633; PubMed Central PMCID: PMC5847168.

Charles Ng (Littman Lab)

Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone JA, Garcia KC. Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science. 2018 Mar 2;359(6379):1037-1042. doi: 10.1126/science.aar3246. PubMed PMID: 29496879; PubMed Central PMCID: PMC5947856.

December 12, 2017

December 5, 2017

Geunhyo Jang

Pan W, Zhu S, Qu K, Meeth K, Cheng J, He K, Ma H, Liao Y, Wen X, Roden C, Tobiasova Z, Wei Z, Zhao J, Liu J, Zheng J, Guo B, Khan SA, Bosenberg M, Flavell RA, Lu J. The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression. Immunity. 2017 Aug 15;47(2):284-297.e5. doi: 10.1016/j.immuni.2017.07.020. PubMed PMID: 28813659; PubMed Central PMCID: PMC5710009.

Anastasia Zavitsanou

Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K. Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells. Cell Rep. 2017 Nov 14;21(7):1824-1838. doi: 10.1016/j.celrep.2017.10.082. PubMed PMID: 29141216.

November 28, 2017

Maria Lafaille

Minutti CM, Drube S, Blair N, Schwartz C, McCrae JC, McKenzie AN, Kamradt T, Mokry M, Coffer PJ, Sibilia M, Sijts AJ, Fallon PG, Maizels RM, Zaiss DM. Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion. Immunity. 2017 Oct 17;47(4):710-722.e6. doi: 10.1016/j.immuni.2017.09.013. PubMed PMID: 29045902; PubMed Central PMCID: PMC5654729.

November 21, 2017

Alice Kwon

Zhang S, Takaku M, Zou L, Gu AD, Chou WC, Zhang G, Wu B, Kong Q, Thomas SY, Serody JS, Chen X, Xu X, Wade PA, Cook DN, Ting JPY, Wan YY. Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation. Nature. 2017 Nov 2;551(7678):105-109.

Denis Loredan

Machiels B, Dourcy M, Xiao X, Javaux J, Mesnil C, Sabatel C, Desmecht D, Lallemand F, Martinive P, Hammad H, Guilliams M, Dewals B, Vanderplasschen A, Lambrecht BN, Bureau F, Gillet L. A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes. Nat Immunol. 2017 Oct 16. doi: 10.1038/ni.3857

November 14, 2017

Jason Hall (Littman Lab)

Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 Nov 16;551(7680):340-345. doi: 10.1038/nature24302. Epub 2017 Nov 8. Erratum in: Nature. 2017 Nov 22;:. Nature. 2018 Jul 4;:. PubMed PMID: 29144460; PubMed Central PMCID: PMC5884449.

James Muller (Dustin Lab)

Wang P, Xu J, Wang Y, Cao X. An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism. Science. 2017 Nov 24;358(6366):1051-1055. doi: 10.1126/science.aao0409. Epub 2017 Oct 26. PubMed PMID: 29074580.

November 7, 2017

Maria Pokrovskii (Littman Lab)

Mass E, Jacome-Galarza CE, Blank T, Lazarov T, Durham BH, Ozkaya N, Pastore A, Schwabenland M, Chung YR, Rosenblum MK, Prinz M, Abdel-Wahab O, Geissmann F. A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease. Nature. 2017 Sep 21;549(7672):389-393 Mass

Sean Saunders (Maria Lafaille Lab)

Mayer CT, Gazumyan A, Kara EE, Gitlin AD, Golijanin J, Viant C, Pai J, Oliveira TY, Wang Q, Escolano A, Medina-Ramirez M, Sanders RW, Nussenzweig MC. The microanatomic segregation of selection by apoptosis in the germinal center. Science. 2017 Oct 13;358(6360). pii: eaao2602 Mayer

October 31, 2017

Varsha Raghavan (Littman Lab)

Hoytema van Konijnenburg DP, Reis BS, Pedicord VA, Farache J, Victora GD, Mucida D. Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection. Cell. 2017 Nov 2;171(4):783-794.e13 Hoytema van Konijnenburg

Hernandez Moura Silva (Lafaille Lab)

Atarashi K, Suda W, Luo C, Kawaguchi T, Motoo I, Narushima S, Kiguchi Y, Yasuma K, Watanabe E, Tanoue T, Thaiss CA, Sato M, Toyooka K, Said HS, Yamagami H, Rice SA, Gevers D, Johnson RC, Segre JA, Chen K, Kolls JK, Elinav E, Morita H, Xavier RJ, Hattori M, Honda K. Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation. Science. 2017 Oct 20;358(6361):359-365 Atarashi

October 17, 2017

Tariq Najar (Littman Lab)

Dang EV, McDonald JG, Russell DW, Cyster JG. Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. Cell. 2017 Oct 7. pii: S0092-8674(17)31123-6. doi: 10.1016/j.cell.2017.09.029. [Epub ahead of print] PubMed PMID: 29033131. Dang

Jhimmy Talbot (Littman Lab)

Isoda T, Moore AJ, He Z, Chandra V, Aida M, Denholtz M, Piet van Hamburg J, Fisch KM, Chang AN, Fahl SP, Wiest DL, Murre C. Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate. Cell. 2017 Sep 21;171(1):103-119.e18 Isoda

October 3, 2017

Mo Xu (Littman Lab)

Bunker JJ, Erickson SA, Flynn TM, Henry C, Koval JC, Meisel M, Jabri B, Antonopoulos DA, Wilson PC, Bendelac A (2017) Natural polyreactive IgA antibodies coat the intestinal microbiota. Science. 28 Sep 2017: DOI: 10.1126/science.aan6619 Bunker

Michelle Krogsgaard (Krogsgaard Lab)

Li L, Guo X, Shi X, Li C, Wu W, Yan C, Wang H, Li H, Xu C. Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5891-E5899 Li

September 26, 2017

Priya Issuree (Littman Lab)

Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 Sep 15; 357(6356): 1156-1160 Geller

Susan Schwab (Schwab lab)

Tassetto M, Kunitomi M, Andino R. Circulating Immune Cells Mediate a Systemic RNAi-Based Adaptive Antiviral Response in Drosophila. Cell. 2017 Apr 6;169(2):314-325.e13 Tassetto

September 19, 2017

Oriana Perez (Reizis Lab)

Ribas A, Dummer R, Puzanov I, VanderWalde A, Andtbacka RHI, Michielin O, Olszanski AJ, Malvehy J, Cebon J, Fernandez E, Kirkwood JM, Gajewski TF, Chen L, Gorski KS, Anderson AA, Diede SJ, Lassman ME, Gansert J, Hodi FS, Long GV. Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy. Cell. 2017 Sep 7;170(6):1109-1119 Ribas

September 12, 2017

Doua Azzouz (Silverman Lab)

Magri G, Comerma L, Pybus M, Sintes J, Lligé D, Segura-Garzón D, Bascones S, Yeste A, Grasset EK, Gutzeit C, Uzzan M, Ramanujam M, van Zelm MC, Albero-González R, Vazquez I, Iglesias M, Serrano S, Márquez L, Mercade E, Mehandru S, Cerutti A. Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals. Immunity. 2017 Jul 18;47(1):118-134.e8 Magri

Charles Ng (Littman Lab)

Cardoso V, Chesné J, Ribeiro H, García-Cassani B, Carvalho T, Bouchery T, Shah K, Barbosa-Morais NL, Harris N, Veiga-Fernandes H. Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. Nature. 2017 Sep 6. doi: 10.1038/nature23469. [Epub ahead of print] PubMed PMID: 28869974. Cardoso 

September 5, 2017

Margaret Warren (Reizis Lab)

Baratin M, Simon L, Jorquera A, Ghigo C, Dembele D, Nowak J, Gentek R, Wienert S, Klauschen F, Malissen B, Dalod M, Bajénoff M. T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node. Immunity. 2017 Aug 15;47(2):349-362.e5. doi: 10.1016/j.immuni.2017.07.019. Epub 2017 Aug 8. PubMed PMID: 28801233. Baratin

Katharine Lu Yang (Koralov Lab)

Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature. 2017 Aug 16. doi: 10.1038/nature23643. [Epub ahead of print] PubMed PMID: 28813417. Burr

August 29, 2017

Yu Matsuzawa (Cadwell Lab)

Zhang D, Chia C, Jiao X, Jin W, Kasagi S, Wu R, Konkel JE, Nakatsukasa H, Zanvit P, Goldberg N, Chen Q, Sun L, Chen ZJ, Chen W. D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 2017 Sep;23(9):1036-1045 Zhang

Axel Concepcion (Feske Lab)

Patel SJ, Sanjana NE, Kishton RJ, Eidizadeh A, Vodnala SK, Cam M, Gartner JJ, Jia L, Steinberg SM, Yamamoto TN, Merchant AS, Mehta GU, Chichura A, Shalem O, Tran E, Eil R, Sukumar M, Guijarro EP, Day CP, Robbins P, Feldman S, Merlino G, Zhang F, Restifo NP. Identification of essential genes for cancer immunotherapy. Nature. 2017 Aug 31;548(7669):537-542 Patel

August 22, 2017

Ioanna Tiniakou (Reizis Lab)

Kwong B, Rua R, Gao Y, Flickinger J Jr, Wang Y, Kruhlak MJ, Zhu J, Vivier E, McGavern DB, Lazarevic V. T-bet-dependent NKp46(+) innate lymphoid cells regulate the onset of T(H)17-induced neuroinflammation. Nat Immunol. 2017 Aug 14. doi: 10.1038/ni.3816. [Epub ahead of print] PubMed PMID: 28805812. Kwong

Hao Xu (Littman Lab)

Li D, Meng L, Xu T, Su Y, Liu X, Zhang Z, Wang X. RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. Elife. 2017 Aug 15;6. pii: e27692. doi: 10.7554/eLife.27692 Li

August 15, 2017

Jessica Neil (Cadwell Lab)

Cervantes-Barragan L, Chai JN, Tianero MD, DiLuccia B, Ahern PP, Merriman J, Cortez VS, Caparon MG, Donia MS, Gilfillan S, Cella M, Gordon JI, Hsieh CS, Colonna M. Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8αα(+) T cells. Science. 2017 Aug 3. pii: eaah5825. doi: 10.1126/science.aah5825 Cervantes-Barragan

Brian Norris (Ernst Lab)

Galani IE, Triantafyllia V, Eleminiadou EE, Koltsida O, Stavropoulos A, Manioudaki M, Thanos D, Doyle SE, Kotenko SV, Thanopoulou K, Andreakos E. Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness. Immunity. 2017 May 16;46(5):875-890.e6 Galani

August 8, 2017

Boris Reizis (Reizis Lab)

Takizawa H, Fritsch K, Kovtonyuk LV, Saito Y, Yakkala C, Jacobs K, Ahuja AK, Lopes M, Hausmann A, Hardt WD, Gomariz Á, Nombela-Arrieta C, Manz MG. Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness. Cell Stem Cell. 2017 Jul 19. pii: S1934-5909(17)30239-4 Takizawa

Matt Keller (Cadwell Lab)

Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502 Steed

August 1, 2017

Ulrike Kaufmann (Feske Lab)

Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Cañete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, Wirtz S, Schett G, Distler JHW, Ramming A. Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells. Nat Med. 2017 Jul 17. doi: 10.1038/nm.4373. [Epub ahead of print] PubMed PMID: 28714991. Rauber

Hannah Fehlner-Peach (Littman Lab)

Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol. 2017 May;18(5):552-562. Mariño

July 25, 2017

Juan Lafaille (Lafaille Lab)

Leonard JD, Gilmore DC, Dileepan T, Nawrocka WI, Chao JL, Schoenbach MH, Jenkins MK, Adams EJ, Savage PA. Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen. Immunity. 2017 Jul 18;47(1):107-117.e8. Leonard

July 18, 2017

Duane Moogk (Krogsgaard Lab)

Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017 Jul 13;547(7662):217-221 Ott

Patricia Martin (Cadwell Lab)

St Leger AJ, Desai JV, Drummond RA, Kugadas A, Almaghrabi F, Silver P, Raychaudhuri K, Gadjeva M, Iwakura Y, Lionakis MS, Caspi RR. An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells. Immunity. 2017 Jul 18;47(1):148-158.e5 St Leger

July 11, 2017

Sascha Kahlfuss (Feske Lab)

Laffont S, Blanquart E, Savignac M, Cénac C, Laverny G, Metzger D, Girard JP, Belz GT, Pelletier L, Seillet C, Guéry JC. Androgen signaling negatively controls group 2 innate lymphoid cells. J Exp Med. 2017 Jun 5;214(6):1581-1592 Laffont

Audrey Baeyens (Schwab Lab)

Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017 Jun 29;546(7660):667-670 Zhu

June 20, 2017

Joel Ernst (Ernst Lab)

Moguche AO, Musvosvi M, Penn-Nicholson A, Plumlee CR, Mearns H, Geldenhuys H, Smit E, Abrahams D, Rozot V, Dintwe O, Hoff ST, Kromann I, Ruhwald M, Bang P, Larson RP, Shafiani S, Ma S, Sherman DR, Sette A, Lindestam Arlehamn CS, McKinney DM, Maecker H, Hanekom WA, Hatherill M, Andersen P, Scriba TJ, Urdahl KB. Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis. Cell Host Microbe. 2017 Jun 14;21(6):695-706.e5. Moguche

Martin Vaeth (Feske Lab)

Shan Q, Zeng Z, Xing S, Li F, Hartwig SM, Gullicksrud JA, Kurup SP, Van Braeckel-Budimir N, Su Y, Martin MD, Varga SM, Taniuchi I, Harty JT, Peng W, Badovinac VP, Xue HH. The transcription factor Runx3 guards cytotoxic CD8(+) effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol. 2017 Jun 12. doi: 10.1038/ni.3773. [Epub ahead of print] PubMed PMID:28604718. Shan

June 13, 2017

Raquel Arifa (Lafaille Lab)

Overacre-Delgoffe AE, Chikina M, Dadey RE, Yano H, Brunazzi EA, Shayan G, Horne W, Moskovitz JM, Kolls JK, Sander C, Shuai Y, Normolle DP, Kirkwood JM, Ferris RL, Delgoffe GM, Bruno TC, Workman CJ, Vignali DAA. Interferon-γ Drives T(reg) Fragility to Promote Anti-tumor Immunity. Cell. 2017 Jun 1;169(6):1130-1141.e11 Overacre-Delgoffe

June 6, 2017

Lin Wu (Littman Lab)

Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell. 2017 Jun 1;169(6):1119-1129.e11. doi: 10.1016/j.cell.2017.05.002. Epub 2017 May 25. PubMed PMID: 28552347. Ali

Ali Rashidfarrokhi (Reizis Lab)

Ip WKE, Hoshi N, Shouval DS, Snapper S, Medzhitov R. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 2017 May 5;356(6337):513-519. doi: 10.1126/science.aal3535. PubMed PMID: 28473584. Ip

May 30, 2017

June-Yong Lee (Littman Lab)

Minutti CM, Jackson-Jones LH, García-Fojeda B, Knipper JA, Sutherland TE, Logan N, Rinqvist E, Guillamat-Prats R, Ferenbach DA, Artigas A, Stamme C, Chroneos ZC, Zaiss DM, Casals C, Allen JE. Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. Science. 2017 May 11. pii: eaaj2067. doi: 10.1126/science.aaj2067. [Epub ahead of print] PubMed PMID:28495878. Minutti

Eugene Rudensky (Cadwell Lab)

Morales AJ, Carrero JA, Hung PJ, Tubbs AT, Andrews JM, Edelson BT, Calderon B, Innes CL, Paules RS, Payton JE, Sleckman BP. A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages. Elife. 2017 Mar 31;6. pii: e24655. doi: 10.7554/eLife.24655. PubMed PMID: 28362262; PubMed Central PMCID: PMC5409825. Morales

May 23, 2017

Maria Pokrovskii (Littman Lab)

Lis R, Karrasch CC, Poulos MG, Kunar B, Redmond D, Duran JGB, Badwe CR, Schachterle W, Ginsberg M, Xiang J, Tabrizi AR, Shido K, Rosenwaks Z, Elemento O, Speck NA, Butler JM, Scandura JM, Rafii S. Conversion of adult endothelium to immunocompetent haematopoietic stem cells. Nature. 2017 May 17. doi: 10.1038/nature22326. [Epub ahead of print] PubMed PMID: 28514438. Lis

Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017 May 17. doi: 10.1038/nature22370. [Epub ahead of print] PubMed PMID: 28514439. Sugimura

Ludovic Desvignes (Ernst Lab)

Wolf Y, Boura-Halfon S, Cortese N, Haimon Z, Sar Shalom H, Kuperman Y, Kalchenko V, Brandis A, David E, Segal-Hayoun Y, Chappell-Maor L, Yaron A, Jung S. Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure. Nat Immunol. 2017 Jun;18(6):665-674. doi: 10.1038/ni.3746. Epub 2017 May 1. PubMed PMID: 28459435. Wolf

May 2, 2017

James Muller (Dustin Lab)

Lu P, Shih C, Qi H. Ephrin B1-mediated repulsion and signaling control germinal center T cell territoriality and function. Science. 2017 Apr 13. pii: eaai9264. doi: 10.1126/science.aai9264. [Epub ahead of print] PubMed PMID: 28408722. Lu

Maria Lafaille (M. Lafaille Lab)

Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell. 2017 Apr 20;169(3):497-509.e13. doi: 10.1016/j.cell.2017.03.044. PubMed PMID: 28431248. Van Dyken

April 25, 2017

Adam Pelzek (Silverman Lab)

Turner JS, Marthi M, Benet ZL, Grigorova I. Transiently antigen-primed B cells return to naive-like state in absence of T-cell help. Nat Commun. 2017 Apr 21;8:15072 Turner

April 18, 2017

Varsha Raghavan (Littman Lab)

Moor K, Diard M, Sellin ME, Felmy B, Wotzka SY, Toska A, Bakkeren E, Arnoldini M, Bansept F, Co AD, Völler T, Minola A, Fernandez-Rodriguez B, Agatic G, Barbieri S, Piccoli L, Casiraghi C, Corti D, Lanzavecchia A, Regoes RR, Loverdo C, Stocker R, Brumley DR, Hardt WD, Slack E. High-avidity IgA protects the intestine by enchaining growing bacteria. Nature. 2017 Apr 12. doi: 10.1038/nature22058. [Epub ahead of print] PubMed PMID: 28405025 Moor

Sean Saunders (M. Lafaille Lab)

Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain PO, Schandene L, Casartelli N, Rameix-Welti MA, Hervé PL, Dériaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eléouët JF, Riffault S, Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissières P, Lo-Man R. Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity. Immunity. 2017 Feb 21;46(2):301-314 Zhivaki

April 11, 2017

Jhimmy Talbot (Littman Lab)

Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017 Apr 7;356(6333):44-50 Bouziat

Hernandez Moura Silva (Lafaille Lab)

Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan SZ, Liu Y. The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nat Immunol. 2017 Mar 27. doi: 10.1038/ni.3709. [Epub ahead of print] PubMed PMID: 28346409. Shan

April 4, 2017

Mo Xu (Littman Lab)

Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Cell. 2017 Mar 23;169(1):108-119.e20. doi: 10.1016/j.cell.2017.03.006. PubMed PMID: 28340336. Taylor

P'ng Loke (Loke Lab)

Piccolo V, Curina A, Genua M, Ghisletti S, Simonatto M, Sabò A, Amati B, Ostuni R, Natoli G. Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk. Nat Immunol. 2017 Mar 13. doi: 10.1038/ni.3710. [Epub ahead of print] PubMed PMID: 28288101. Piccolo

March 28, 2017

Priya Issuree (Littman Lab)

Choi S, Warzecha C, Zvezdova E, Lee J, Argenty J, Lesourne R, Aravind L, Love PE. THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1. Nat Immunol. 2017 Apr;18(4):433-441 Choi

Ken Cadwell (Cadwell Lab)

Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D, Benoist C. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell. 2017 Mar 9;168(6):1135-1148.e12 Yissachar

March 21, 2017

Charles Ng (Littman Lab)

Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, Sica GL, Sharpe AH, Freeman GJ, Blazar BR, Turka LA, Owonikoko TK, Pillai R, Ramalingam SS, Araki K, Ahmed R. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science. 2017 Mar 9. pii: eaaf0683. doi: 10.1126/science.aaf0683. [Epub ahead of print] PubMed PMID:28280249. Kamphorst

March 14, 2017

Doua Azzouz (Silverman Lab)

Geva-Zatorsky N, Sefik E, Kua L, Pasman L, Tan TG, Ortiz-Lopez A, Yanortsang TB, Yang L, Jupp R, Mathis D, Benoist C, Kasper DL. Mining the Human Gut Microbiota for Immunomodulatory Organisms. Cell. 2017 Feb 23;168(5):928-943 Geva-Zatorsky

Susan Schwab (Schwab Lab)

Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017 Feb 20. doi: 10.1038/nature21379. [Epub ahead of print] PubMed PMID: 28219080. Pan

March 7, 2017

Katharine Yang (Koralov Lab)

Spath S, Komuczki J, Hermann M, Pelczar P, Mair F, Schreiner B, Becher B. Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System. Immunity. 2017 Feb 21;46(2):245-260 Spath

Margaret Warren (Reizis Lab)

Sakamoto K, Kim Y-G, Hara H, Kamada N, Caballero-Flores G, Tolosano E, Soares MP, Puente JL, Inohara N, Núñez G. 2017. IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections. Science Immunology. 03 Feb 2017. Vo. 2, Issue 8. DOI: 10.1126/sciimmunol.aai8371

February 28, 2017

Yu Matsuzawa (Cadwell Lab)

Karki R, Man SM, Malireddi RK, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P, Kanneganti TD. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016 Dec 12. doi: 10.1038/nature20597. [Epub ahead of print] PubMed PMID: 27951586. Karki

February 21, 2017

Ioanna Tiniakou (Reizis Lab)

Menezes S, Melandri D, Anselmi G, Perchet T, Loschko J, Dubrot J, Patel R, Gautier EL, Hugues S, Longhi MP, Henry JY, Quezada SA, Lauvau G, Lennon-Duménil AM, Gutiérrez-Martínez E, Bessis A, Gomez-Perdiguero E, Jacome-Galarza CE, Garner H, Geissmann F, Golub R, Nussenzweig MC, Guermonprez P. The Heterogeneity of Ly6C(hi) Monocytes Controls Their Differentiation into iNOS(+) Macrophages or Monocyte-Derived Dendritic Cells. Immunity. 2016 Dec 20;45(6):1205-1218 Menezes

Mick Ménager (Littman Lab)

Chen J, Ganguly A, Mucsi AD, Meng J, Yan J, Detampel P, Munro F, Zhang Z, Wu M, Hari A, Stenner MD, Zheng W, Kubes P, Xia T, Amrein MW, Qi H, Shi Y. Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy. J Exp Med. 2017 Feb;214(2):327-338 Chen

Yan J, Liu B, Shi Y, Qi H. Class II MHC-independent suppressive adhesion of dendritic cells by regulatory T cells in vivo. J Exp Med. 2017 Feb;214(2):319-326 Yan

February 14, 2017

Vanja Sisirak (Reizis Lab)

Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W. CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Immunity In Press Corrected Proof DOI: http://dx.doi.org/10.1016/j.immuni.2017.01.003 Brewitz

Axel Concepcion (Feske Lab)

Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB. Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature. 2017 Feb 1;542(7639):110-114 Rao

February 7, 2017

Hao Xu (Littman Lab)

Chen C, Itakura E, Nelson GM, Sheng M, Laurent P, Fenk LA, Butcher RA, Hegde RS, de Bono M. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Nature. 2017 Feb 2;542(7639):43-48 Chen

Jessica Neil (Cadwell Lab)

Glenn JD, Smith MD, Xue P, Chan-Li Y, Collins S, Calabresi PA, Horton MR, Whartenby KA. CNS-targeted autoimmunity leads to increased influenza mortality in mice. J Exp Med. 2017 Jan 5. pii: jem.20160517. doi: 10.1084/jem.20160517. [Epub ahead of print] PubMed PMID: 28057805. Glenn

January 31, 2017

Brian Norris (Ernst Lab)

Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C. Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses. Immunity. 2017 Jan 17;46(1):120-132 Druzd

Matt Keller (Cadwell Lab)

Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, Dong M, Chen Y, Ismail N, Ndung'u T, Ghebremichael MS, Wesemann DR, Mitchell C, Dong KL, Huttenhower C, Walker BD, Virgin HW, Kwon DS. Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women. Immunity. 2017 Jan 17;46(1):29-37 Gosmann 

January 24, 2017

Boris Reizis (Reizis Lab)

Das A, Heesters BA, Bialas A, O'Flynn J, Rifkin IR, Ochando J, Mittereder N, Carlesso G, Herbst R, Carroll MC. Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses. Immunity. 2017 Jan 17;46(1):106-119. doi: 10.1016/j.immuni.2016.12.014. PubMed PMID: 28099860. Das

Ulrike Kaufmann (Feske Lab)

Dutzan N, Abusleme L, Bridgeman H, Greenwell-Wild T, Zangerle-Murray T, Fife ME, Bouladoux N, Linley H, Brenchley L, Wemyss K, Calderon G, Hong BY, Break TJ, Bowdish DM, Lionakis MS, Jones SA, Trinchieri G, Diaz PI, Belkaid Y, Konkel JE, Moutsopoulos NM. On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier. Immunity. 2017 Jan 17;46(1):133-147 Dutzan

January 17, 2017

Hannah Fehlner-Peach (Littman Lab)

Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Horst RT, Jansen T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LA, Zhernakova A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ. Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity. Cell. 2016 Dec 15;167(7):1897 Schirmer

Duane Moogk (Krogsgaard Lab)

Dutta D, Barr VA, Akpan I, Mittelstadt PR, Singha LI, Samelson LE, Ashwell JD. Recruitment of calcineurin to the TCR positively regulates T cell activation. Nat Immunol. 2016 Dec 12. doi: 10.1038/ni.3640. [Epub ahead of print] PubMed PMID:27941787. Dutta

January 10, 2017

Patricia Martin (Cadwell Lab)

Nuñez S, Moore C, Gao B, Rogers K, Hidalgo Y, del Nido PJ, Restaino S, Naka Y, Bhagat G, Madsen JC, Bono MR, Zorn E. 2016. The human thymus perivascular space is a functional niche for viral-specific plasma cells. Science Immunology 1(6) DOI: 10.1126/sciimmunol.aah4447

Audrey Baeyens (Schwab Lab)

H, Griggs N, Velasco-Herrera MD, Tüting T, Sansom OJ, Karp NA, Clare S, Gleeson D, Ryder E, Galli A, Tuck E, Cambridge EL, Voet T, Macaulay IC, Wong K; Sanger Mouse Genetics Project., Spiegel S, Speak AO, Adams DJ. Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature. 2017 Jan 12;541(7636):233-236 Weyden

January 3, 2017

Juan Lafaille (Lafaille Lab)

Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 2014 Jul 1;20(1):61-72 Macintyre

Martin Vaeth (Feske Lab)

Tyrakis PA, Palazon A, Macias D, Lee KL, Phan AT, Veliça P, You J, Chia GS, Sim J, Doedens A, Abelanet A, Evans CE, Griffiths JR, Poellinger L, Goldrath AW, Johnson RS. S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate. Nature. 2016 Dec 8;540(7632):236-241 Tyrakis

December 13, 2016

Lin Wu (Littman Lab)

Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet MF, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease. Cell. 2016 Dec 1;167(6):1469-1480.e12. doi: 10.1016/j.cell.2016.11.018. PubMed PMID: 27912057. Sampson

Maryaline Coffre (Koralov Lab)

de Kleer IM, Kool M, de Bruijn MJ, Willart M, van Moorleghem J, Schuijs MJ, Plantinga M, Beyaert R, Hams E, Fallon PG, Hammad H, Hendriks RW, Lambrecht BN. Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung. Immunity. 2016 Dec 5. pii: S1074-7613(16)30442-3. doi: 10.1016/j.immuni 2016.10.031. [Epub ahead of print] PubMed PMID: 27939673. de Kleer

December 6, 2016

Joel Ernst (Ernst Lab)

Miyauchi K, Sugimoto-Ishige A, Harada Y, Adachi Y, Usami Y, Kaji T, Inoue K, Hasegawa H, Watanabe T, Hijikata A, Fukuyama S, Maemura T, Okada-Hatakeyama M, Ohara O, Kawaoka Y, Takahashi Y, Takemori T, Kubo M. Protective neutralizing influenza antibody response in the absence of T follicular helper cells. Nat Immunol. 2016 Dec;17(12):1447-1458. doi: 10.1038/ni.3563. PubMed PMID: 27798619. Miyauchi

Ali Rashidfarrokhi (Reizis Lab)

Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science. 2016 Nov 11;354(6313):765-768. PubMed PMID: 27846608. Hu

November 29, 2016

Eugene Rudensky (Cadwell Lab)

Enyedi B, Jelcic M, Niethammer P. The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation. Cell. 2016 May 19;165(5):1160-70. doi: 10.1016/j.cell.2016.04.016. PubMed PMID: 27203112; PubMed Central PMCID: PMC4875569. Enyedi

Raquel Duque do Nascimento Arifa (Lafaille Lab)

Tsagaratou A, González-Avalos E, Rautio S, Scott-Browne JP, Togher S, Pastor WA, Rothenberg EV, Chavez L, Lähdesmäki H, Rao A. TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells. Nat Immunol. 2016 Nov 21. doi: 10.1038/ni.3630. [Epub ahead of print] PubMed PMID: 27869820. Tsagaratou

November 22, 2016

June-Yong Lee (Littman Lab)

Cummings RJ, Barbet G, Bongers G, Hartmann BM, Gettler K, Muniz L, Furtado GC, Cho J, Lira SA, Blander JM. Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs. Nature. 2016 Nov 9. doi: 10.1038/nature20138. [Epub ahead of print] PubMed PMID: 27828940. Cummings

Ludovic Desvignes (Ernst Lab)

Cronan MR, Beerman RW, Rosenberg AF, Saelens JW, Johnson MG, Oehlers SH, Sisk DM, Jurcic Smith KL, Medvitz NA, Miller SE, Trinh LA, Fraser SE, Madden JF, Turner J, Stout JE, Lee S, Tobin DM. Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection. Immunity. 2016 Oct 18;45(4):861-876 Cronan

November 15, 2016

Maria Pokrovskii (Littman Lab)

Vély F, Barlogis V, Vallentin B, Neven B, Piperoglou C, Ebbo M, Perchet T, Petit M, Yessaad N, Touzot F, Bruneau J, Mahlaoui N, Zucchini N, Farnarier C, Michel G, Moshous D, Blanche S, Dujardin A, Spits H, Distler JH, Ramming A, Picard C, Golub R, Fischer A, Vivier E. Evidence of innate lymphoid cell redundancy in humans. Nat Immunol. 2016 Nov;17(11):1291-1299 Vély

November 8, 2016

Maria Lafaille (M. Lafaille Lab)

Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, Vogt K, Kollet J, Babel N, Sawitzki B, Schwarz C, Bereswill S, Heimesaat MM, Heine G, Gadermaier G, Asam C, Assenmacher M, Kniemeyer O, Brakhage AA, Ferreira F, Wallner M, Worm M, Scheffold A. Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell. 2016 Nov 3;167(4):1067-1078 Bacher

Hernandez Moura Silva (Lafaille Lab)

Yu Y, Tsang JC, Wang C, Clare S, Wang J, Chen X, Brandt C, Kane L, Campos LS, Lu L, Belz GT, McKenzie AN, Teichmann SA, Dougan G, Liu P. Single-cell RNA-seq identifies a PD-1(hi) ILC progenitor and defines its development pathway. Nature. 2016 Sep 29;539(7627):102-106 Yu

November 1, 2016

Jason Hall (Littman Lab)

Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, Drake AM, Chen Z, Sen D, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM, Vahedi G, Haining WN, Berger SL, Wherry EJ. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science. 2016 Oct 27. pii: aaf2807. [Epub ahead of print] PubMed PMID: 27789795. Pauken

Adam Pelzek (Silverman Lab)

Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH. Suppression by T(FR) cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Oct 3. doi: 10.1038/ni.3578. [Epub ahead of print] PubMed PMID: 27695002. Sage

October 25, 2016

Jhimmy Talbot (Littman Lab)

Geiger R, Rieckmann JC, Wolf T, Basso C, Feng Y, Fuhrer T, Kogadeeva M, Picotti P, Meissner F, Mann M, Zamboni N, Sallusto F, Lanzavecchia A. L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Cell. 2016 Oct 20;167(3):829-842.e13 Geiger

Varsha Raghavan (Littman Lab)

Pelczar P et al. A pathogenic role for T cell–derived IL-22BP in inflammatory bowel disease. Science. 354(6310): 358-362

October 11, 2016

Mo Xu (Littman Lab)

Chudnovskiy A, Mortha A, Kana V, Kennard A, Ramirez JD, Rahman A, Remark R, Mogno I, Ng R, Gnjatic S, Amir ED, Solovyov A, Greenbaum B, Clemente J, Faith J, Belkaid Y, Grigg ME, Merad M. Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome. Cell. 2016 Oct 6;167(2):444-456.e14 Chudnovskiy

P'ng Loke (Loke Lab)

Wilhelm C, Harrison OJ, Schmitt V, Pelletier M, Spencer SP, Urban JF Jr, Ploch M, Ramalingam TR, Siegel RM, Belkaid Y. Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection. J Exp Med. 2016 Jul 25;213(8):1409-18 Wilhelm

October 4, 2016

Priya Issuree (Littman Lab)

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem C, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PI3Kγ is a molecular switch that controls immune suppression. Nature. 2016 Sep 19. doi: 10.1038/nature19834. [Epub ahead of print] PubMed PMID: 27642729. Kaneda

Ken Cadwell (Cadwell Lab)

Rangan, K. J., V. A. Pedicord, Y.-C. Wang, B. Kim, Y. Lu, S. Shaham, D. Mucida and H. C. Hang (2016). "A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens." Science 353(6306): 1434-1437.

September 27, 2016

James Muller (Dustin Lab)

Wang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R. Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation. Cell. 2016 Sep 8;166(6):1512-1525.e12. doi: 10.1016/j.cell.2016.07.026. PubMed PMID: 27610573. Wang

September 20, 2016

Katharine Lu Yang (Koralav Lab)

JH, Palmer DC, Gros A, Yamamoto TN, Patel SJ, Guittard GC, Yu Z, Carbonaro V, Okkenhaug K, Schrump DS, Linehan WM, Roychoudhuri R, Restifo NP. Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature. 2016 Sep 14. doi: 10.1038/nature19364. [Epub ahead of print] PubMed PMID: 27626381. Eil

Charles Ng (Littman Lab)

Di Marco Barros R, Roberts NA, Dart RJ, Vantourout P, Jandke A, Nussbaumer O, Deban L, Cipolat S, Hart R, Iannitto ML, Laing A, Spencer-Dene B, East P, Gibbons D, Irving PM, Pereira P, Steinhoff U, Hayday A. Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments. Cell. 2016 Sep 13. pii: S0092-8674(16)31081-9. doi: 10.1016/j.cell.2016.08.030. [Epub ahead of print] PubMed PMID: 27641500. Di Marco Barros

September 13, 2016

Vickie Fang (Schwab Lab)

Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Aug 11;166(4):841-54 Odegaard

September 6, 2016

Yu Matsuzawa (Cadwell Lab)

Damgaard RB, Walker JA, Marco-Casanova P, Morgan NV, Titheradge HL, Elliott PR, McHale D, Maher ER, McKenzie AN, Komander D. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016 Aug 25;166(5):1215-1230.e20. doi: 10.1016/j.cell.2016.07.019. Epub 2016 Aug 11. PubMed PMID: 27523608. Damgaard

August 30, 2016

Hao Xu (Littman Lab)

Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW. Discovery of a proteinaceous cellular receptor for a norovirus. Science. 2016 Aug 26;353(6302):933-6 Orchard

Axel Concepcion (Feske Lab)

Utzschneider DT, Charmoy M, Chennupati V, Pousse L, Ferreira DP, Calderon-Copete S, Danilo M, Alfei F, Hofmann M, Wieland D, Pradervand S, Thimme R, Zehn D, Held W. T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections. Immunity. 2016 Aug 16;45(2):415-27. Utzschneider

August 23, 2016

Matthew Keller (Cadwell Lab)

Malchow S, Leventhal DS, Lee V, Nishi S, Socci ND, Savage PA. Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage. Immunity. 2016 May 17;44(5):1102-13. doi: 10.1016/j.immuni.2016.02.009. Epub 2016 Apr 26. PubMed PMID: 27130899; PubMed Central PMCID: PMC4871732. Malchow

Susan Schwab (Schwab Lab)

Malhotra D, Linehan JL, Dileepan T, Lee YJ, Purtha WE, Lu JV, Nelson RW, Fife BT, Orr HT, Anderson MS, Hogquist KA, Jenkins MK. Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns. Nat Immunol. 2016 Feb;17(2):187-95. doi: 10.1038/ni.3327. Epub 2016 Jan 4. PubMed PMID: 26726812; PubMed Central PMCID: PMC4718891. Malhotra

August 16, 2016

Brian Norris (Ernst Lab)

Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Wang C, Fang-Hoover J, Harris E, Pereira L. Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission. Cell Host Microbe. 2016 Aug 10;20(2):155-166. doi: 10.1016/j.chom.2016.07.002. Epub 2016 Jul 18. PubMed PMID:27443522. Tabata

Jessica Neil (Cadwell Lab)

Leong YA, Chen Y, Ong HS, Wu D, Man K, Deleage C, Minnich M, Meckiff BJ, Wei Y, Hou Z, Zotos D, Fenix KA, Atnerkar A, Preston S, Chipman JG, Beilman GJ, Allison CC, Sun L, Wang P, Xu J, Toe JG, Lu HK, Tao Y, Palendira U, Dent AL, Landay AL, Pellegrini M, Comerford I, McColl SR, Schacker TW, Long HM, Estes JD, Busslinger M, Belz GT, Lewin SR, Kallies A, Yu D. CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol. 2016 Aug 3. doi: 10.1038/ni.3543. [Epub ahead of print] PubMed PMID: 27487330. Leong

August 9, 2016

Juan Lafaille (Lafaille Lab)

Wyss L, Stadinski BD, King CG, Schallenberg S, McCarthy NI, Lee JY, Kretschmer K, Terracciano LM, Anderson G, Surh CD, Huseby ES, Palmer E. Affinity for self antigen selects T(reg) cells with distinct functional properties. Nat Immunol. 2016 Aug 1. doi: 10.1038/ni.3522. [Epub ahead of print] PubMed PMID: 27478940. Wyss

Ulrike Kaufmann (Feske Lab)

Campisi L, Barbet G, Ding Y, Esplugues E, Flavell RA, Blander JM. Apoptosis in response to microbial infection induces autoreactive T(H)17 cells. Nat Immunol. 2016 Jul 25. doi: 10.1038/ni.3512. [Epub ahead of print] PubMed PMID: 27455420. Campisi

July 26, 2016

Hannah Fehlner-Peach (Littman Lab)

Gomez de Agüero M, Ganal-Vonarburg SC, Fuhrer T, Rupp S, Uchimura Y, Li H, Steinert A, Heikenwalder M, Hapfelmeier S, Sauer U, McCoy KD, Macpherson AJ. The maternal microbiota drives early postnatal innate immune development. Science. 2016 Mar 18;351(6279):1296-302 Gomez de Agüero

Kirsten Wiens (Ernst Lab)

Smith AA, Navasa N, Yang X, Wilder CN, Buyuktanir O, Marques A, Anguita J, Pal U. Cross-Species Interferon Signaling Boosts Microbicidal Activity within the Tick Vector. Cell Host Microbe. 2016 Jul 13;20(1):91-8. doi: 10.1016/j.chom.2016.06.001. Epub 2016 Jun 30. PubMed PMID: 27374407; PubMed Central PMCID: PMC4945435. Smith

July 19, 2016

Patricia Martin (Cadwell Lab)

Wolf AJ, Reyes CN, Liang W, Becker C, Shimada K, Wheeler ML, Cho HC, Popescu NI, Coggeshall KM, Arditi M, Underhill DM. Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan. Cell. 2016 Jun 29. pii: S0092-8674(16)30723-1. doi: 10.1016/j.cell.2016.05.076. [Epub ahead of print] PubMed PMID: 27374331. Wolf

Audrey Baeyens (Schwab Lab)

Cibrian D, Saiz ML, de la Fuente H, Sánchez-Díaz R, Moreno-Gonzalo O, Jorge I, Ferrarini A, Vázquez J, Punzón C, Fresno M, Vicente-Manzanares M, Daudén E, Fernández-Salguero PM, Martín P, Sánchez-Madrid F. CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis. Nat Immunol. 2016 Jul 4. doi: 10.1038/ni.3504. [Epub ahead of print] PubMed PMID: 27376471. Cibrian

July 12, 2016

Raquel Arifa (Lafaille Lab)

Stadinski BD, Shekhar K, Gómez-Touriño I, Jung J, Sasaki K, Sewell AK, Peakman M, Chakraborty AK, Huseby ES. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nat Immunol. 2016 Jun 27. doi: 10.1038/ni.3491. [Epub ahead of print] PubMed PMID: 27348411. Stadinski

July 5, 2016

Wendy Huang (Littman Lab)

Faber F, Tran L, Byndloss MX, Lopez CA, Velazquez EM, Kerrinnes T, Nuccio SP, Wangdi T, Fiehn O, Tsolis RM, Bäumler AJ. Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. Nature. 2016 Jun 15;534(7609):697-699 Faber

June 28, 2016

Maryaline Coffre (Koralov Lab)

Tellier J, Shi W, Minnich M, Liao Y, Crawford S, Smyth GK, Kallies A, Busslinger M, Nutt SL. Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response. Nat Immunol. 2016 Mar;17(3):323-30. doi: 10.1038/ni.3348. Epub 2016 Jan 18. PubMed PMID: 26779600; PubMed Central PMCID: PMC4757736. Tellier

Martin Vaeth (Feske Lab)

Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL. Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. Cell. 2016 Jun 8. pii: S0092-8674(16)30586-4. doi: 10.1016/j.cell.2016.05.035. [Epub ahead of print] PubMed PMID: 27293185. Buck

June 21, 2016

Lin Wu (Littman Lab)

Iijima N, Iwasaki A. Access of protective antiviral antibody to neuronal tissues requires CD4 T-cell help. Nature. 2016 May 18;533(7604):552-6. doi: 10.1038/nature17979. PubMed PMID: 27225131; PubMed Central PMCID: PMC4883597. Iijima

Ludovic Desvignes (Ernst Lab)

Pulko V, Davies JS, Martinez C, Lanteri MC, Busch MP, Diamond MS, Knox K, Bush EC, Sims PA, Sinari S, Billheimer D, Haddad EK, Murray KO, Wertheimer AM, Nikolich-Žugich J. Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses. Nat Immunol. 2016 Jun 6. doi: 10.1038/ni.3483. [Epub ahead of print] PubMed PMID: 27270402. Pulko

June 14, 2016

Michelle Krogsgaard (Krogsgaard Lab)

Strønen E, Toebes M, Kelderman S, van Buuren MM, Yang W, van Rooij N, Donia M, Böschen ML, Lund-Johansen F, Olweus J, Schumacher TN. Targeting of cancer neoantigens with donor-derived T cell receptor repertoires. Science. 2016 May 19. pii: aaf2288. [Epub ahead of print] PubMed PMID: 27198675. Strønen

Mate Maus (Feske Lab)

Pollizzi KN, Sun IH, Patel CH, Lo YC, Oh MH, Waickman AT, Tam AJ, Blosser RL, Wen J, Delgoffe GM, Powell JD. Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation. Nat Immunol. 2016 Jun;17(6):704-11. doi: 10.1038/ni.3438. Epub 2016 Apr 11. PubMed PMID: 27064374; PubMed Central PMCID: PMC4873361. Pollizzi

June 7, 2016

Dan Littman (Littman Lab)

Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science. 2016 Apr 21. pii: aaf3036. [Epub ahead of print] PubMed PMID: 27103670. Zanoni

Michael Gonzalez (Loke Lab)

Okin D, Medzhitov R. The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia. Cell. 2016 Apr 7;165(2):343-56 Okin

May 31, 2016

Maria Lafaille (M. Lafaille Lab)

Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13;352(6287):aaf4822. doi: 10.1126/science.aaf4822. PubMed PMID: 27174992 Reboldi

Maria Pokrovskii (Littman Lab)

Rialdi A, Campisi L, Zhao N, Lagda AC, Pietzsch C, Ho JS, Martinez-Gil L, Fenouil R, Chen X, Edwards M, Metreveli G, Jordan S, Peralta Z, Munoz-Fontela C, Bouvier N, Merad M, Jin J, Weirauch M, Heinz S, Benner C, van Bakel H, Basler C, García-Sastre A, Bukreyev A, Marazzi I. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science. 2016 Apr 28. pii: aad7993. [Epub ahead of print] PubMed PMID: 27127234. Rialdi

May 24, 2016

June-Yong Lee (Littman Lab)

Mackay LK, Minnich M, Kragten NA, Liao Y, Nota B, Seillet C, Zaid A, Man K, Preston S, Freestone D, Braun A, Wynne-Jones E, Behr FM, Stark R, Pellicci DG, Godfrey DI, Belz GT, Pellegrini M, Gebhardt T, Busslinger M, Shi W, Carbone FR, van Lier RA, Kallies A, van Gisbergen KP. Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Science. 2016 Apr 22;352(6284):459-63 Mackay

Hernandez Moura Silva (Lafaille Lab)

Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016 May 27;352(6289):1116-20 Chu

May 17, 2016

Adam Pelzek (Silverman Lab)

Zeng MY, Cisalpino D, Varadarajan S, Hellman J, Warren HS, Cascalho M, Inohara N, Núñez G. Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens. Immunity. 2016 Mar 15;44(3):647-58 Zeng

Varsha Raghavan (Littman Lab)

Vatanen T, Kostic AD, d'Hennezel E, Siljander H, Franzosa EA, Yassour M, Kolde R, Vlamakis H, Arthur TD, Hämäläinen AM, Peet A, Tillmann V, Uibo R, Mokurov S, Dorshakova N, Ilonen J, Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H, Huttenhower C, Gevers D, Cullen TW, Knip M; DIABIMMUNE Study Group, Xavier RJ. Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans. Cell. 2016 May 5;165(4):842-53 Vatanen

May 10, 2016

Jhimmy Talbot (Littman Lab)

Koch MA, Reiner GL, Lugo KA, Kreuk LS, Stanbery AG, Ansaldo E, Seher TD, Ludington WB, Barton GM. Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life. Cell. 2016 May 5;165(4):827-41 Koch

May 3, 2016

James Muller (Dustin Lab)

Verbist KC, Guy CS, Milasta S, Liedmann S, Kamiński MM, Wang R, Green DR. Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature. 2016 Apr 21;532(7599):389-93 Verbist

Ken Cadwell (Cadwell Lab)

Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D. Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature. 2016 Apr 20. doi: 10.1038/nature17655. [Epub ahead of print] PubMed PMID: 27096360. Beura

April 19, 2016

Priya Issuree (Littman Lab)

Wang J, Kubes P. A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair. Cell. 2016 Apr 6. pii: S0092-8674(16)30265-3. doi: 10.1016/j.cell.2016.03.009. [Epub ahead of print] PubMed PMID: 27062926. Wang

Mo Xu (Littman Lab)

Fourgeaud L, Través PG, Tufail Y, Leal-Bailey H, Lew ED, Burrola PG, Callaway P, Zagórska A, Rothlin CV, Nimmerjahn A, Lemke G. TAM receptors regulate multiple features of microglial physiology. Nature. 2016 Apr 14;532(7598):240-4 Fourgeaud

April 12, 2016

Katharine Yang (Koralav Lab)

Yang W, Bai Y, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu C, Yan C, Wang L, Chang CC, Chang TY, Zhang T, Zhou P, Song BL, Liu W, Sun SC, Liu X, Li BL, Xu C (2016) Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature. 531(7596):651-5 Yang

Charles Ng (Littman Lab)

Muñoz-Ruiz M, Ribot JC, Grosso AR, Gonçalves-Sousa N, Pamplona A, Pennington DJ, Regueiro JR, Fernández-Malavé E, Silva-Santos B. TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets. Nat Immunol. 2016 Apr 4. doi: 10.1038/ni.3424. [Epub ahead of print] PubMed PMID: 27043412. Muñoz-Ruiz

April 5, 2016

Doua Azzouz (Silverman Lab)

Ruane D, Chorny A, Lee H, Faith J, Pandey G, Shan M, Simchoni N, Rahman A, Garg A, Weinstein EG, Oropallo M, Gaylord M, Ungaro R, Cunningham-Rundles C, Alexandropoulos K, Mucida D, Merad M, Cerutti A, Mehandru S. (2016) Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses. J Exp Med. 213(1):53-73. Ruane

Sang-Won Kim (Littman Lab)

Esterházy D, Loschko J, London M, Jove V, Oliveira TY, Mucida D. Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance. Nat Immunol. 2016 Mar 28. doi: 10.1038/ni.3408. [Epub ahead of print] PubMed PMID: 27019226. Esterházy

March 29, 2016

Vickie Fang (Schwab Lab)

Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF. (2016) NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. Nature. 531(7593):253-7 Ma

Jessica Neil (Cadwell Lab)

C. Nakahashi-Oda, K. G. S. Udayanga, Y. Nakamura, Y. Nakazawa, N. Totsuka, H. Miki, S. Iino, S. Tahara-Hanaoka, S.-i. Honda, K. Shibuya and A. Shibuya. Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces. Nat Immunol. 2016. 17(4): 441-450. Nakahashi-Oda

March 22, 2016

Mick Ménager (Littman Lab)

Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W, Oyler-Yaniv A, Dotiwala F, Giannone G, Hivroz C, Biais N, Lieberman J, Kam LC, Huse M. Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell. 2016 Feb 24. pii: S0092-8674(16)00061-1. doi: 10.1016/j.cell.2016.01.021. [Epub ahead of print] PubMed PMID: 26924577. Basu

Duane Moogk (Krogsgaard Lab)

Gros A, Parkhurst MR, Tran E, Pasetto A, Robbins PF, Ilyas S, Prickett TD, Gartner JJ, Crystal JS, Roberts IM, Trebska-McGowan K, Wunderlich JR, Yang JC, Rosenberg SA. Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients. Nat Med. 2016 Feb 22. doi: 10.1038/nm.4051. [Epub ahead of print] PubMed PMID: 26901407. Gros

March 15, 2016

Yu Matsuzawa (Cadwell Lab)


Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057. PubMed PMID: 26919428; PubMed Central PMCID: PMC4769378. Zhong

Hao Xu (Littman Lab)

Withers DR, Hepworth MR, Wang X, Mackley EC, Halford EE, Dutton EE, Marriott CL, Brucklacher-Waldert V, Veldhoen M, Kelsen J, Baldassano RN, Sonnenberg GF. Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing T(H)17 cells and preserving group 3 innate lymphoid cells. Nat Med. 2016 Feb 15. doi: 10.1038/nm.4046. [Epub ahead of print] PubMed PMID: 26878233. Withers

March 8, 2016

Matthew Keller (Cadwell Lab)

Kabat AM, Harrison OJ, Riffelmacher T, Moghaddam AE, Pearson CF, Laing A, Abeler-Dörner L, Forman SP, Grencis RK, Sattentau Q, Simon AK, Pott J, Maloy KJ. The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. Elife. 2016 Feb 24;5. pii: e12444. doi: 10.7554/eLife.12444. [Epub ahead of print] PubMed PMID: 26910010. Kabat

March 1, 2016

Hannah Fehlner-Peach (Littman Lab)

Kim KS, Hong SW, Han D, Yi J, Jung J, Yang BG, Lee JY, Lee M, Surh CD. Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine. Science. 2016 Feb 19;351(6275):858-63 Kim

Brian Norris (Ernst Lab)

Tas JM, Mesin L, Pasqual G, Targ S, Jacobsen JT, Mano YM, Chen CS, Weill JC, Reynaud CA, Browne EP, Meyer-Hermann M, Victora GD. Visualizing antibody affinity maturation in germinal centers. Science. 2016 Feb 18. pii: aad3439. [Epub ahead of print] PubMed PMID: 26912368. Tas

February 23, 2016

Juan Lafaille (Lafaille Lab)

Park Y, Jin HS, Lopez J, Lee J, Liao L, Elly C, Liu YC. SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex. Nat Immunol. 2016 Mar;17(3):286-96 Park

Kirsten Wiens (Ernst Lab)

Long JS, Giotis ES, Moncorgé O, Frise R, Mistry B, James J, Morisson M, Iqbal M, Vignal A, Skinner MA, Barclay WS. Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature. 2016 Jan 7;529(7584):101-4 Long

February 16, 2016

Patricia Martin (Cadwell Lab)

Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, Weinstock JV, Gallini CA, Redding K, Margolskee RF, Osborne LC, Artis D, Garrett WS. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science. 2016 Feb 4. pii: aaf1648. [Epub ahead of print] PubMed PMID: 26847546. Howitt

Teruyuki Sano (Littman Lab)

Pillay S, Meyer NL, Puschnik AS, Davulcu O, Diep J, Ishikawa Y, Jae LT, Wosen JE, Nagamine CM, Chapman MS, Carette JE. An essential receptor for adeno-associated virus infection. Nature. 2016 Jan 27. doi: 10.1038/nature16465. [Epub ahead of print] PubMed PMID: 26814968. Pillay

February 9, 2016

Joel Ernst (Ernst Lab)

Tan J, Pieper K, Piccoli L, Abdi A, Foglierini M, Geiger R, Tully CM, Jarrossay D, Ndungu FM, Wambua J, Bejon P, Fregni CS, Fernandez-Rodriguez B, Barbieri S, Bianchi S, Marsh K, Thathy V, Corti D, Sallusto F, Bull P, Lanzavecchia A. A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature. 2016 Jan 7; 529 (7584): 105-9 Tan

Ulrike Kaufmann (Feske Lab)

Luo CT, Liao W, Dadi S, Toure A, Li MO. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016 Jan 28; 529 (7587): 532-6 Luo

February 2, 2016

Audrey Baeyens (Schwab Lab)

Kiermaier E, Moussion C, Veldkamp CT, Gerardy-Schahn R, de Vries I, Williams LG, Chaffee GR, Phillips AJ, Freiberger F, Imre R, Taleski D, Payne RJ, Braun A, Förster R, Mechtler K, Mühlenhoff M, Volkman BF, Sixt M. Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science. 2016 Jan 8;351(6269):186-90 Kiermaier

January 26, 2016

Wendy Huang (Littman Lab)

York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell. 2015 Dec 17;163(7):1716-29 York

Martin Vaeth (Feske Lab)

Jain R, Chen Y, Kanno Y, Joyce-Shaikh B, Vahedi G, Hirahara K, Blumenschein WM, Sukumar S, Haines CJ, Sadekova S, McClanahan TK, McGeachy MJ, O'Shea JJ, Cua DJ. Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells. Immunity. 2016 Jan 19;44(1):131-42 Jain

January 19, 2016

Lin Wu (Littman Lab)

von Moltke J, Ji M, Liang HE, Locksley RM. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature. 2016 Jan 14;529(7585):221-5 von Moltke

Maryaline Coffre (Koralav Lab)

Weisel FJ, Zuccarino-Catania GV, Chikina M, Shlomchik MJ. A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells. Immunity. 2016 Jan 19;44(1):116-30 Weisel

January 12, 2016

Ludovic Desvignes (Ernst Lab)

Mujal AM, Gilden JK, Gérard A, Kinoshita M, Krummel MF. A septin requirement differentiates autonomous and contact-facilitated T cell proliferation. Nat Immunol. 2015 Dec 21. doi: 10.1038/ni.3330. [Epub ahead of print] Mujal

Mate Maus (Feske Lab)

Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJ, Tonc E, Schreiber RD, Pearce EJ, Pearce EL. Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression. Cell. 2015 Sep 10;162(6):1229-41 Chang

January 5, 2016

Maria Pokrovskii (Littman Lab)

Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow LE, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MR, Hanash AM. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature. 2015 Dec 24;528(7583):560-4 Lindemans